应用食管多通道腔内阻抗观察不同体质量指数反流性食管炎患者的反流特点

Observation of the reflux characteristics of reflux esophagitis in patients with different body mass indexes using multichannel intraluminal impedance

目的应用多通道腔内阻抗技术联合24 h pH监测(MII-pH)观察不同体质量指数(BMI)的反流性食管炎(RE)患者的反流特点。方法将56例RE患者按照BMI分为正常组、超重组和肥胖组。通过多通道腔内阻抗联合pH监测,观察各研究对象反流相关指标,并对pH监测及阻抗结果进行统计分析。结果与正常组相比,超重组、肥胖组在总体、直立位和仰卧位pH<4时间百分比、酸反流次数和液体反流次数上有统计学差异(P<0.05或0.01),超重组和肥胖组间无统计学差异(P均>0.05)。3组在弱酸反流、非酸反流、混合反流、气体反流、近端反流方面均无统计学差异(P均>0.05)。结论超重和肥胖患者更容易发生酸暴露、酸反流和液体反流,但肥胖程度对酸暴露、酸反流和液体反流的影响无明显差异。

Objective To observe the reflux characteristics of patients with reflux esophagitis in different body mass in- dexes using combined multichannel intraluminal impedance-pH （MII-pH） monitoring. Methods 56 patients with re- flux esophagitis were enrolled and divided into the normal group, overweight group and obesity group according to their body mass indexes. We observed reflux-related indicators of individuals with MII-pH monitoring, and then performed statistical analysis on pH monitoring and impedance results. Results Compared with normal group, there were signifi- cant differences in overweight group and obesity group on percent time pH 〈 4 （total, upright and recumbent）, acid re- flux and liquid reflux （P 〈0.05 or 0.01 ） ,while no significant differences were found between overweight and obesity groups （ all P 〉 0.05 ）. There were no significant differences in weakly acid reflux, non-acid reflux, mixed reflux, gas reflux and proximal reflux episodes among the three groups （ all P 〉 0.05 ）. Conclusion There are more acid expo- sure, acid reflux and liquid reflux episodes in overweight and obese patients; however, the effect of the extent of obesi- ty on acid exposure, acid reflux and liquid reflux has no significant difference.