膀胱内灌注透明质酸钠治疗非细菌性膀胱炎的临床观察

Clinical observation on intravesical instillation of sodium hyaluronate for treatment of non-bacterial cystitis

目的观察膀胱内灌注透明质酸钠治疗非细菌性膀胱炎的疗效及安全性。方法对28例非细菌性膀胱炎患者行膀胱内灌注透明质酸钠溶液(50 mL/40 mg),每周灌注1次,连续4周;后改为两周1次,连续4周;最后每月灌注1次,连续2月。两周随访1次,随访至第16周,根据患者主观感受填写疼痛视觉模拟量表VAS、LUTS症状评分、记录排尿日记,观察并分析变化以评价其疗效和安全性。结果 28例患者均完成灌注疗程及随访,第16周时VAS评分由治疗前6.86±1.74下降至2.71±0.90(P<0.001),LUTS评分由治疗前41.07±11.96下降至23.25±6.07(P<0.001);膀胱容量均值由治疗前(106.71±22.65)mL上升至(163.93±32.00)mL(P<0.001)。结论膀胱内灌注透明质酸钠治疗非细菌性膀胱炎的短期疗效及安全性值得肯定,能明显缓解症状,从而提高生活质量。

Objective To observe the clinical efficacy and safety on intravesical instillation of sodium hyaluronate for treatment of non-bacterial cystitis. Methods Totally 28 patients with non-bacterial cystitis were included. They re- ceived intravesical instillation（ sodium hyaluronate solution of 50 ml/40 mg） once a week for 4 weeks, then once every two weeks for the next 4 weeks and at last once a month for the next 2 months. The follow-up visited was performed once every two weeks, ended at the 16th week. Evaluate the efficacy and safety of the sodium hyaluronate according to patients＇ symptom assessment scores （VAS, LUTS） and the micturition diary. Results 28 patients all completed the instillation and follow-up. At the 16th week, the VAS score dropped from 6.86± 1.74 to 2.71±0.90（P 〈0. 001 ）, the LUTS score dropped from 41.07 ±11.96 to 23.25 ± 6.07 （ P 〈 0. 001 ） and the mean BC （ bladder capacity） rose from （106.71 ±22.65）mL to （163.93±32.00）mL（P 〈0.001）. Conclusion The short-term curative effect and safety of intravesical instillation of sodium hyaluronate to treat the non-bacterial cystitis is worth affirmation. It can sig- nificantly relieve symptoms in order to improve the quality of life.