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胚胎自我修复 被引量:1

Self-correction in human embryos
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摘要 人类早期胚胎存在较高比例的染色体异常现象。近年来,随着检测技术的不断进步,人们对胚胎染色体异常的认识也在逐步加深。2005年先后有报道,染色体异常的早期胚胎可发生部分或全部胚胎细胞的自我修复,但自我修复率及其相关机制尚未明确。以下就这方面的研究进展进行综述。 Reanalysis of aneuploid embryos diagnosed by preimplantation genetic screening(PGS) using fluorescence in situ hybridization(FISH)showed that part or all cells in some human cleavage-stage embryos may undergo self-correction during preimplantation development. Putative embryo self-correction mechanisms include embryonic mosaicism, preferential segregation of chromosomal abnormalities to the trophectoderm and extrusion or duplication of aneuploid chromosomes resulting in uniparental disomy. However,embryo self-correction has not been proved in the study using a single nucleotide polymorphism (SNP)microarray-based 24 chromosome aneuploidy screening technology. Neither preferential segregation of aneuploidy to trophectoderm nor uniparental disomy was found. Further study to improve the accuracy of karyotyping on cleavage-stage embryos is definitely needed.
作者 徐艳文
出处 《生殖医学杂志》 CAS 2013年第1期1-3,共3页 Journal of Reproductive Medicine
关键词 胚胎 荧光原位杂交 植入前遗传学诊断 Embryo FISH Preimplantation genetic diagnosis
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参考文献11

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