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DNA甲基化与结直肠癌的预后及治疗进展 被引量：6

Progress of DNA methylation in prognosis and treatment of colorectal cancer
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摘要 DNA甲基化是结直肠癌常见的表观遗传性改变,甲基化的异常可引起肿瘤癌基因的激活以及抑癌基因的失活,因此在结直肠癌的发生发展中有重要的意义。DNA甲基化的改变可导致结直肠癌出现不同的预后。且因为甲基化过程是可逆的,故其有望成为结直肠癌治疗新靶点。 DNA methylation has been recognized as a common epigenetic change in colorectal cancer,aberrant methylation can lead to activation of oncogene and inactivation of tumor suppressor gene,therefore this will play an important role in the genesis and development of cancer.Alteration of DNA methylation curses different prognosis of colorectal cancer.Because of reversibility of DNA methylation,it is expected to become a new target for treatment.This summary overviews DNA methylation in the prognosis and treatment of cotorectal cancer in brief.
作者 王春晓 罗开元
机构地区 昆明医科大学第四附属医院 云南省第二人民医院普外科
出处 《中国医药科学》 2013年第1期48-51,共4页 China Medicine And Pharmacy
基金 云南省科技厅基金面上项目资助(2010ZC221)
关键词 DNA甲基化 结直肠癌 预后 治疗 DNA methylation Colorectal cancer Prognosis Treatment
分类号 R735.37 [医药卫生—肿瘤]
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共引文献46

同被引文献46

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  • 10Mohammad Reza Abbaszadegan,Omeed Moaven,Hamid Reza Sima,Kamran Ghafarzadegan,Azadeh A'rabi,Mohammad Naser Forghani,Hamid Reza Raziee,Ali Mashhadinejad,Mostafa Jafarzadeh,Ehsan Esmaili-Shandiz,Ezzat Dadkhah.p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer[J].World Journal of Gastroenterology,2008,14(13):2055-2060. 被引量：50

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中国医药科学
2013年 第1期

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