摘要
目的:探讨晚期下咽鳞癌中FAS表达及其与下咽鳞癌临床病理因素关系。方法:免疫组化方法检测41例晚期下咽鳞癌组织中FAS表达,分析FAS表达与临床病理因素及预后的关系。结果:在41例晚期下咽鳞癌中,FAS阳性表达率为39.0%。病理分化Ⅰ级和Ⅲ级患者FAS阳性表达率分别为61.5%和23.5%(P<0.05)。颈部淋巴结转移和无颈部淋巴结转移患者FAS表达阳性率分别为18.2%和63.2%(P<0.05)。诱导化疗敏感患者和化疗不敏感患者的FAS表达阳性率分别为57.9%和22.7%(P<0.05)。年龄和T分期与FAS表达无相关性。FAS阳性表达患者5年生存率为52.8%,阴性表达患者为16.1%(P<0.05)。多因素分析显示FAS表达是下咽鳞癌预后差的独立预测因素,均P<0.05。结论:在晚期下咽鳞癌中,存在FAS表达,FAS表达可以作为下咽鳞癌病理分化、颈部淋巴结转移、化疗敏感和预后的预测因子。
Objective: To investigate the expression of FAS in advanced hypopharyngeal squamous cell carcinoma (AHPSCC) and its relationship to clinical pathological parameters and prognosis.Methods: The expression of FAS was detected by immunohistochemical method in AHPSCC tissues in forty one patients, and it relation to clinical pathological or prognosis was analyzed.Results: The positive expression rate of FAS was 39.0% in forty one patients with AHPSCC. The positive expression rate of FAS was 61.5% and 23.5% respectively for patients with grade I and grade III respectively with significant difference (P〈0.05). The expression positive rate of FAS in patients without lymph node metastasis and sensitive to chemotherapy was 63.2% and 57.9% respectively, and was respectively higher than that with cervical lymph node metastasis and chemotherapy resistance (18.2% and 22.7% respectively, both P〈0.05). No significant as sociation were observed between FAS expression and gender, age, or T stage. Significance difference existed in 5-year survival rate between FAS positive and negative expression patients (52.8% versus 16.1%, P〈0.05). A higher level of FAS expression was a beneficial prognosis factor for AHPSCC by univariate and multivariate analysis, P〈0.05. respectively. Conclusion: The expression of FAS was found in AHPSCC tissues, and the positive expression of FAS may serve as a predictive factor for poor differentiation, lymph node metastasis, chemotherapy resistant and poor prognosis in AHPSCC.
出处
《武汉大学学报(医学版)》
CAS
北大核心
2013年第1期31-34,共4页
Medical Journal of Wuhan University
基金
海南省医学科学研究基金资助项目(编号:200935)
关键词
喉咽
肿瘤
FAS
分化
转移
化疗
敏感性
预后
Hypopharyngeal
Neoplasm
FAS
Differentiation
Metastasis
Chemotherapy
Sensitivity
Prognosis