FAS在下咽鳞癌中的表达及临床病理意义

Expression of FAS in Advanced Hypopharyngeal Squamous Cell Carcinoma and Its Clinicopathological Significance

目的:探讨晚期下咽鳞癌中FAS表达及其与下咽鳞癌临床病理因素关系。方法:免疫组化方法检测41例晚期下咽鳞癌组织中FAS表达,分析FAS表达与临床病理因素及预后的关系。结果:在41例晚期下咽鳞癌中,FAS阳性表达率为39.0%。病理分化Ⅰ级和Ⅲ级患者FAS阳性表达率分别为61.5%和23.5%(P<0.05)。颈部淋巴结转移和无颈部淋巴结转移患者FAS表达阳性率分别为18.2%和63.2%(P<0.05)。诱导化疗敏感患者和化疗不敏感患者的FAS表达阳性率分别为57.9%和22.7%(P<0.05)。年龄和T分期与FAS表达无相关性。FAS阳性表达患者5年生存率为52.8%,阴性表达患者为16.1%(P<0.05)。多因素分析显示FAS表达是下咽鳞癌预后差的独立预测因素,均P<0.05。结论:在晚期下咽鳞癌中,存在FAS表达,FAS表达可以作为下咽鳞癌病理分化、颈部淋巴结转移、化疗敏感和预后的预测因子。

Objective： To investigate the expression of FAS in advanced hypopharyngeal squamous cell carcinoma （AHPSCC） and its relationship to clinical pathological parameters and prognosis.Methods： The expression of FAS was detected by immunohistochemical method in AHPSCC tissues in forty one patients, and it relation to clinical pathological or prognosis was analyzed.Results： The positive expression rate of FAS was 39.0% in forty one patients with AHPSCC. The positive expression rate of FAS was 61.5% and 23.5% respectively for patients with grade I and grade III respectively with significant difference （P〈0.05）. The expression positive rate of FAS in patients without lymph node metastasis and sensitive to chemotherapy was 63.2% and 57.9% respectively, and was respectively higher than that with cervical lymph node metastasis and chemotherapy resistance （18.2% and 22.7% respectively, both P〈0.05）. No significant as sociation were observed between FAS expression and gender, age, or T stage. Significance difference existed in 5-year survival rate between FAS positive and negative expression patients （52.8% versus 16.1%, P〈0.05）. A higher level of FAS expression was a beneficial prognosis factor for AHPSCC by univariate and multivariate analysis, P〈0.05. respectively. Conclusion： The expression of FAS was found in AHPSCC tissues, and the positive expression of FAS may serve as a predictive factor for poor differentiation, lymph node metastasis, chemotherapy resistant and poor prognosis in AHPSCC.