寻常性银屑病患者外周血中IL-17、IL-18水平变化及其与PASI评分的相关性分析

Changes of Interleukin-17 and Interleukin-18 Leves in Peripheral Blood of Patients with Psoriasis Vulgaris and Their Correlation to PASI Score

目的:探讨lL-17、IL-18在寻常性银屑病患者外周血清中的变化及其与皮损面积和严重程度指数(PASI评分)的相关性。方法:采用双抗体夹心酶联免疫吸附法(ELISA)检测30例寻常性银屑病患者和15例健康对照者外周血IL-17和IL-18水平,并和PSAI评分相关因素进行分析。结果:30例寻常性银屑病患者与15例健康对照者比较,其外周血中IL-17、IL-18的水平明显增高,差异均有显著统计学意义(P<0.01);23例进行期寻常性银屑病患者与7例静止期寻常性银屑病患者比较,其外周血中IL-17、IL-18的水平明显增高,差异有统计学意义(P<0.05)。30例寻常性银屑病患者血清IL-17和IL-8水平与PASI评分呈正相关(r_(17)=0.739 8,P<0.001)(r_(18)=0.328 8,P<0.001)。结论:IL-17和IL-18可能与寻常性银屑病的发病有关,且与该疾病的活动性有一定的相关性。

Objective. To investigate the changes of interleukin-17 （IL-17） and interleukin-18 （IL-18） levels in peripheral blood of patients with psoriasis vulgaris, and to explore their correlation to psoriasis area and severity index （PASI）. Methods： Enzyme linked immunosorbent assay （ELISA） was used to measure the blood serum level of IL-17 and IL-18 from 30 psoriasis vulgaris patients, and 15 healthy persons as control. The correlation between the IL-17/IL-18 levels and PASI scores was analyzed. Results. The levels of IL-17 and IL-18 were significantly higher in psoriasis vulgaris group than in control group （both P〈0.01）, and also, the IL-17/IL-18 levels were different between 23 cases of active psoriasis vulgaris and 7 cases of stable psoriasis vulgaris （P〈0.05）. The blood serum levels of IL-17/IL-18 in psoriasis vulgaris patients was positively associated with PASI scores （r17=0. 739 8, P〈0. 001; r18 =0. 328 8, P〈0. 001）. Conclusion： IL-17 and IL-18 may play an important role in the pathogenesis of psoriasis vulgaris, and they are also correlated with the disease activity.