高级别脑胶质瘤术后同步放化疗的疗效观察

Efficacy of high grade brain malignant glioma treated with postoperative concurrent chemoradiotherapy

目的:探讨脑胶质瘤术后行同步放化疗的疗效。方法:选取74例高级别脑胶质瘤患者,随机分为放疗组(A组)和放疗+化疗组(B组),每组各37例。A组术后行三维适形放疗,每次3-4Gy,3次/周,共15-20次,总剂量56-60Gy。B组除给予A组相同的放疗外,还接受替莫唑胺(TMZ)同期化疗,化疗完毕比较两组患者的整体疗效及生活质量。结果:B组完全缓解12例,部分缓解15例,有效率为72.97%;而A组完全缓解只有5例。部分缓解7例,有效率占32.43%。两组疗效比较,差异具有统计学意义(P<0.01)。KPS评分比较,差异也具有统计学意义(P<0.01)。结论:脑胶质瘤术后同步放化疗,有明显疗效,优于单纯放疗。

Objective：To explore the clinical effects of brain malignant glioma treated with postoperative radiother- apy and chemotherapy. Methods： Selected 74 cases of glioma, which randomly divided into radiation group （A） and radiotherapy plus chemotherapy group （B） ,37 patients in each group. Group A treated with postoperative three -di- mensional conformal radiotherapy, 3 -4Gy each time ,3 times/week, a total of 15 to 20 times ,56 -60Gy total dose. Giving group B the same radiation with group A, in addition, group B received temozolomide （TMZ） concurrent chem- otherapy. Results：There were 12 cases in group B completely eased. 15 cases were partial remission,the effective rate was 72.97% ;but only 5 cases were complete remission in group A ,7 cases were partial remission, efficiency was 32.43%. Comparison of two groups, the difference was statistically significant （P 〈 0.01 ）. KPS score in 2 groups, thedifference was also statistically significant （P 〈 O. O1 ）. Conclusion： Concurrent chemoradiotherapy is more effective than radiotherapy alone in postoperative malignant glioma.