E2F1在食管癌中的表达及其临床意义

Expression and clinical significance of E2F1 in esophageal cancer

目的:探讨E2F1在食管癌患者中的表达及其与临床病理特征的关系。方法:采用免疫组化法对内镜活检确诊的80例食管癌标本石蜡切片进行染色,并取同体距离癌组织4cm以上的正常食管上皮组织40例作为对照。免疫组化染色检测E2F1的表达,并分析其与食管癌临床病理特征的关系。结果:E2F1蛋白在食管癌组织中阳性表达率显著高于癌旁正常食管组织。E2F1的表达与食管癌浸润深度、淋巴结转移和临床分期、病理类型、病灶大小密切相关(P<0.05),而与患者的性别、年龄、肿瘤分化程度等无明显相关(P>0.05)。结论:E2F1在食管癌组织中表达状态与食管癌发生发展关系密切,对食管癌患者预后评估有一定的参考价值。

Objective：To investigate the expression of E2F1 and its clinical pathological significance in esophageal cancer tissues. Methods：The expression of E2F1 protein in 80 specimens of esophageal cancer was detected by im- munohistochemistry. Forty normal specimens more than 4 cm away from the cancer focus were controls. The correlation of E2F1 expression to clinical pathological parameters was analysed were controls. Results ：The intensive positive rate of E2F1 in esophageal cancer was significantly higher than normal tissues. The expression of E2F1 was highly correla- ted with the clinical stage,lymph node metastasis and T classification （ P 〈 0.05 ）. On the other hand,it was not cor- related with gender, age, or tumor differentiation （P 〉 0.05 ）. Conclusion：The overexpression of E2F1 in esophageal carcinoma enhances the invasion and metastasis. E2F1 may serve as a good prognostic factor to indicate biologic be- havior of esophageal carcinoma, high E2F1 may be a useful predictive marker for malignant potential of esophageal squamous cancer.