髓样肉瘤3例

Three cases of myeloid sarcoma

目的:探讨髓样肉瘤的临床病理特征、诊断及治疗。方法:报告3例我院诊治的髓样肉瘤,并复习相关文献。结果:3例患者均为中青年,发病部位多为淋巴结,可累及小肠、乳腺等;病理免疫组化特征以MPO、CD68阳性为主,CD3、CD20均阴性,Ki-67表达50%左右。结论:髓样肉瘤在基层医院容易误诊为淋巴瘤等,确诊依据病理活检及免疫组化。目前本病治疗欠规范,应予以化疗为主的综合治疗,尚无成熟化疗方案推荐。

Objective： To study myeloid sarcoma＇s clinical and pathological feature, diagnosis and treatment. Methods ： Three cases of myeloid sarcoma diagnosed and treated in Affiliated Hospital of North Sichuan Medical Col- lege were reported, and literatures were reviewed. Results： All three patients suffered with myeloid sarcoma were young people. The position of pathological change was mainly located in lymph nodes, but small intestine and mam- mary glands were often involved. The pathological and immunohistochemical features were shown as follows： MPO and CD68 positive; both CD3 and CD20 negative; and Ki -67 expressed for about 50%. Conclusion： Myeloid sar- coma is easy to be misdiagnosed as lymphoma in lower level hospital. The final diagnosis of myeloid sarcoma is main- ly based on its pathologic biopsy and immunohistochemisty. Currently, no standard treatment schedule for myeloid sarcoma to be recommended, but combined modality therapy mainly included chemotherapy should be considered.