期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

MicroRNAs与糖代谢的研究进展 被引量：1

下载PDF
导出
摘要 MicroRNAs（miRNAs）是一组长约19-25个核苷酸（nucleotides，nt）的小分子非编码RNA，广泛存在于动植物中，在进化过程中高度保守，在阶段性发育、器官发育、细胞分化、信号传导、代谢和肿瘤的发生过程中都发挥了至关重要的作用，近年来发现miRNAs也参与葡萄糖的代谢调节。本文将miRNAs对糖尿病的调节作用综述如下。
作者 刘佳 张宏
机构地区 天津医科大学代谢病医院肥胖代谢科
出处 《天津医药》 CAS 北大核心 2013年第1期83-86,共4页 Tianjin Medical Journal
基金 天津医科大学科学基金项目(项目编号:2011KY26)
关键词 糖尿病 2型 微RNA 胰岛素抗药性 葡萄糖代谢障碍 胰腺 综述
分类号 R394 [医药卫生—医学遗传学]
  • 相关文献

参考文献2

二级参考文献26

  • 1American Diabetes Association. Clinical Practice Recommendations 2001. Diabetes Care 2001 24: S1-S133.
  • 2Adams KF, Schatzkin A, Harris TB, Kipnis V, Mouw T, Ballard-Barbash R and Hollenbeck A, et al. Overweight, obesity, and mortality in a large prospective cohort of persons 50 to 71 years old. N Engl J Med 2006, 355: 763-778.
  • 3Akerblom H. Pathogenesis of Type 1 diabetes: environmental factors. In: Turtle J, Kaneko T and Osato S eds. Diabetes in the New Millennium. Sydney: Endocrinology and Diabetes Research Foundation, University of Sydney, 1999.
  • 4Kahn SE. Clinical review 135: the importance of β-cell failure in the development and progression of type 2 diabetes. J Clin Endocrinol Metab 2001, 86: 4047-4058.
  • 5Steppan CM, Bailey ST, Bhat S, Brown E J, Banerjee RR, Wright CM and Patel HR, et al. The hormone resistin links obesity to diabetes. Nature 2001, 409: 307-312.
  • 6Portha B. Programmed disorders of B-cell development and fimction as one cause for type 2 diabetes? The GK rat paradigm. Diabetes Metab Res Rev 2005, 21: 495-504.
  • 7Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C and Long J, et al. Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rots. J Cell Mol Med 2008; doi:10.1111/ j. 1582-4934.2008.00342.x.
  • 8Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116: 281-297.
  • 9Kato M and Slack FJ. MicmRNAs: small molecules with big roles-C. elegan to human cancer. Biol Cell 2008, 100:71-81.
  • 10Scalbert E and Bril A. Implication of micmRNAs in the cardiovascular system. Curt Opin Pharmacol 2008, 8: 181-188.

共引文献52

同被引文献13

  • 1Zhou N,Mo Y.Roles of micro RNAs in cancer stem cells[J].Frontiersin bioscience(Scholar edition),2011,4:810-818.
  • 2Sreekumar R,Sayan BS,Mirnezami AH,et al.Micro RNA control ofinvasion and metastasis pathways[J].Front Genet,2011,2:58.doi:10.3389/fgene.2011.00058.
  • 3Lammert F,Carey MC,Paigen B.Chromosomal organization of can-didate genes involved in cholesterol gallstone formation:a murinegallstone map[J].Gastroenterology,2001,120(1):221-238.
  • 4Brabletz S,Brabletz T.The ZEB/mi R-200 feedback loop-a motor ofcellular plasticity in development and cancer[J].EMBO Rep,2010,.
  • 5Srivastava K,Srivastava A,Mittal B.Common genetic variants in pre-micro RNAs and risk of gallbladder cancer in North Indian population[J].J Hum Genet,2010,55(8):495-499.
  • 6Wang J,Bi J,Liu X,et al.Has-mi R-146a polymorphism(rs2910164)and cancer risk:a meta-analysis of 19 case–control studies[J].Mol Biol Rep,2012,39(4):4571-4579.doi:10.1007/s11033-011-1247-7.
  • 7Jin K,Xiang Y,Tang J,et al.mi R-34 is associated with poor prognosis of patients with gallbladder cancer through regulating telomere length in tumor stem cells[J].Tumour Biol,2014,35(2):1503-1510.
  • 8Sachdeva M,Mo YY.Micro RNA-145 suppresses cell invasion andmetastasis by directly targeting mucin 1[J].Cancer Res,2010,70(1):378-387.doi:10.1158/0008-5472.CAN-09-2021.
  • 9Inyawilert W,Fu TY,Lin CT,et al.Micro RNA-199a mediates mucin 1 expression in mouse uterus during implantation[J].Reprod Fertil Dev,2014,26(5):653-664.doi:10.1071/RD12097.
  • 10Srivastava SK,Bhardwaj A,Singh S,et al.Micro RNA-150 directly targets MUC4 and suppresses growth and malignant behavior of pancreatic cancercells[J].Carcinogenesis,2011,32(12):1832-1839.doi:10.1093/carcin/bgr223.

引证文献1

二级引证文献3

天津医药
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部