摘要
衰老以器官和组织各种生理功能衰退和其导致机体死亡的可能性增加为特征,遗传与环境都能影响衰老的进程,其中双生子研究发现基因对寿命的贡献在25-30%。各国就衰老基因在模式动物和人群队列中进行了多项研究,发现了很多衰老基因,形成了多种学说。本文就研究衰老基因的方法及发现的主要基因进行综述。
Ageing is typified by the decline of physiological functions in various organs and tissues and leading to an increased probability of death. Aging progress is regulated by combined influence of genetic and environment. Twins studies have indicated that genetic factors account for lifespan approximately 25-30%. Abundant studies about aging-related genetic have been performed in animal models and human cohorts. Many of genes have been identified and several theories established. This review will focus on the research methods of aging genes and important genes have been found.
出处
《中国分子心脏病学杂志》
CAS
2012年第6期380-384,共5页
Molecular Cardiology of China
