127例ALI/ARDS患者肺与大肠证候的Logistic回归分析

Logistic Regression Analysis of Lung and Large Intestine Syndromes of 127 ALI/ARDS Patients

目的探讨急性肺损伤/急性呼吸窘迫综合征(ALI/ARDS)患者肺与大肠证候类型之间的内在联系。方法采集127例ALI/ARDS患者中医证候学信息,采用二项分类Logistic逐步回归分析方法分析肺与大肠证候关系。结果肺系证型占前3位的是痰热壅盛、肺热炽盛和肺气虚证;大肠证型占前3位的是肠热腑实、肠燥津亏和肠道气滞证;肠热腑实和肠燥津亏是痰热壅盛发生的危险因素而肠热腑实与肺气虚负相关;大肠各证候类型的出现均不是肺热炽盛和寒痰阻肺发生的危险因素。结论 ARDS发病过程中,肺与大肠证候之间具有特定和具体的关联形式,在救治过程中可以作为预判病情发展及确定治疗方案的参考。

Objective： To explore the intrinsic link between lung and large intestine syndromes of ALI/ARDS patients. Methods： The information of TCM syndromes were collected fiom 127 ALI/ARDS patients. The relevance between lung and large intestine was analyzed by two classification logistic regression analysis. Results： The top three in lung syndrome types were phlegm-heat obstructing lung, exuberance of lung heat and lung qi deficiency. Intestine heat fu excess,intestinal dry liquid loss and intestinal qi stagnation accounted for the top three in large intestine syndrome types .Intestine heat fu excess and intestinal dry liquid loss were the risk factors of phlegm-heat obstructing lung,while intestine heat fu excess and lung qi deficiency were negatively correlated;the emergence of the large intestine syndromes were not the risk factors to exuberance of lung heat and cold phlegm obstruction lung. Conclusion： There is a particular and specific association form between lung and large intestine syndromes in ARDS pathogenesis,which could be used as a reference to predict the progression and determine therapeutic schedule.