急性胰腺炎患者检测血清IL-18、TNF-α、IL-10的临床意义

Changes and significance of serum interleukin-18、tumor necrosis factor-α and interleukin-10 in acute pancreatitis

①目的探讨血清IL-18、TNF-α、IL-10在急性胰腺炎(AP)患者中变化的临床意义。②方法健康对照组50例,轻症胰腺炎组(MAP)56例,重症胰腺炎(SAP)组患者22例。所有AP患者均在入院后第1、3、7天清晨空腹采血样测血清IL-10、TNF-α、IL-18浓度、并与对照组进进比较。③结果 SAP、MAP组IL-18、TNF-α比对照组明显升高(P<0.05);SAP组比MAP组升高,第1、3天有差别(P<0.05),第7天两组间无差别(P>0.05)。MAP组的IL-10在第1天比对照组明显升高(P<0.05),而SAP组的IL-10在第1天与对照组无差别(P>0.05),第7天比正常对照组、MAP组明显降低(P<0.05)。④结论 IL-18、IL-10、TNF-α参与急性胰腺炎的发病的过程,可作为早期评估胰腺炎症程度的指标,与病情的严重程度有关。

Objective To investigate the changes and significance of pro - inflammatory cytokine interleukin - 18 （ IL - 18） , tumor necrosis factor - α （ TNF - α） and anti - inflammatory cytokine - 10 （ IL - 10） in acute pancreatitis （AP）. Methods Serum IL - 18 ,IL - 10 ,TNF - α were determined quantitatively in 30 healthy persons ,30 MAP patients and 12 SAP patients was made on day 1,3, and 7. Results In both MAP and SAP, serum IL - 18, TNF - α were significantly higher than those in control group （ P 〈 0.05 ）. In SAP group, serum IL - 18 ,TNF - α were siginificantly higher than those in MAP group on day 1 and 3 （ P 〈 0.05）. Se- rum IL- 10 was higher in MAP than that in control group（ P 〈 0.05 ）. Serum IL - 10 was no deferent in SAP group and control group on day 1 （ P 〉 0.05 ）. In SAP group, serum IL - 10 was significantly lower than that in MAP and control group on day 7 （ P 〈 0.05 ）. Conclusion IL - 18, IL - 10,TNF - α play important roles in the development of acute pancreatitis, and they appears to be the earlier marker of severity in acute pancreatitis.