取代二氢异喹啉基苯基甲基酮的合成新方法

New synthesis ways of substitued dihydroisoquinolinylphenylmethanone

以3,4-二甲氧基苯乙酸为原料,经氯化亚砜酰氯化、3,4-二甲氧基苯乙胺氨解得到了N-(3,4-二甲氧基苯乙基)-2-(3,4-二甲氧基苯基)乙酰胺,经Bischler-Napieraski反应环化同时氧化,合成了Lamellarin重要中间体(6,7-二甲氧基-3,4-二氢异喹啉-1-基)(3,4-二甲氧基苯基)甲基酮,优化了环化的反应条件,其总收率为56%。此方法未见文献报道。产物用1H NMR、13C NMR、MS、IR进行了表征。

（ 6,7 -Dimethoxy-3,4 -dihydroisoquinolin-1 -yl ） （3,4-dimethoxyphenyl） methanone was synthesized using 2 - （ 3,4-dime- thoxyphenyl） acetic acid as starting material which was chlorinated by thionyl chloride, ammoniated by 2-（ 3,4-dimethoxyphenyl） ethanamine, followed cyclization and oxidation under Bischler-Napieraski reaction condition, the total yield was 56%. This route had not been reported. The target compound structure was characterized by 1H NMR,13C NMR,MS,IR. The cyclization reaction condi- tions were optimized in this paper.