期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

6-氮杂吲唑-3-羧酸的合成 被引量：1

Synthesis of 1H-pyrazolopyridine-3-carboxylic Acid
下载PDF
导出
摘要 文章以4-氯-3-硝基吡啶为原料,经取代,脱羧,还原,重氮化环合,水解等六步反应,合成了6-氮杂吲唑-3-羧酸,最终产物及中间体的结构经1H NMR和MS确定。 iH-pyrazolo[3,4-c]pyridine-3-carboxylic acid was synthesized by substituted, decarboxylation, reduction, diazotized cyclization and hydrolysis in six-step reactions from 4-chloro-3-nitropyridine. The structure of final compound and all intermediates were confirmed by 1H NMR and MS.
作者 李高楠 夏东 李达超 刘栋 王鹏江 钮智刚
机构地区 海南师范大学化学与化工学院
出处 《广东化工》 CAS 2013年第1期1-2,共2页 Guangdong Chemical Industry
基金 海南师范大学博士科研启动基金资助项目
关键词 4-氯-3-硝基吡啶 氮杂吲唑 合成 4-chloro-3-nitropyridine； aza indazole； synthesis
分类号 O621.3 [理学—有机化学]
  • 相关文献

参考文献8

  • 1Huang L J, Shih M L, Chen H S, et al. Synthesis of N"-substituted (benzyl)-3-(4-methylphenyl)indazoles as novel anti-angiogenic agents[J]. BioorgMedChem, 2006, 14(2): 528-536.
  • 2蔡可迎,宗志敏,魏贤勇.吲唑的简便合成[J].化学试剂,2007,29(1):53-54. 被引量：5
  • 3Kyowa Hakko Kogyo CO., Ltd., Tokyo: EP1847532 A1, 2005.
  • 4Corsi G Palazzo G Germani C et al. 1-Halobenzyl-lH-indazole-3-carboxylic acids. A new class of antislaermatoenic aentsfJ], J Med Chem, 1976, 19(6): 778-783.
  • 5Coulston t:. Perspectives for the use of indazole carboxylic acid as male antifertilityagents[J]. Chemotherapy, 1981, 27(Supp. 12): 98-101.
  • 6Bistochi G A, De Meo G, Pedini M. Nl-substituted lH-indazole-3-ethyl carboxylates and lH-indazole-3-hydroxamic acids[J]. Farmaco Ed Sci, 1981, 36: 315-333.
  • 7Bermudez J, Fake C S, Joiner G F, et al. 5-Hydroxytryptamine(5-HT3) receptor antagonists. 1. Indazole and indolizine-3-carboxylic acid derivatives[J]. J Med Chem, 1990, 33(7): 1924-1929.
  • 8周斌.5-HT_3受体拮抗剂止吐药的研究开发概况[J].药学进展,1992,16(4):210-213. 被引量：7

二级参考文献11

  • 1SONG J J,YEE N K.Synthesis of 1-aryl-1H-indazoles via the palladium-catalyzed cyclization of N-aryl-N'-(o-bromobenzyl)hydrazines and[N-aryl-N'-(o-bromobenzyl)-hydrazinato-N']-triphenyl-phosphonium bromides[J].Tetrahedron Lett.,2001,42(16):2 937-2 940.
  • 2HUANG Li-jiau,SHIH Mei-ling,CHEN Hua-sin,et al.Synthesis of N2-(substituted benzyl)-3-(4-methylphenyl) indazoles as novel anti-angiogenic agents[J].Bioorg.Med.Chem.,2006,14(2):528-536.
  • 3HEINZ R S,BLECKMAN,MICHAEL T K,et al.Synthesis of disubstituted indazole compounds as cyclin dependent kinase inhibitors and methods for inhibiting cell proliferation:WO,2 001 053 268[P].2001-07-26.
  • 4HARI Y,SHOJI Y,AOYAMA T.Regioselective synthesis of 1-arylindazoles via N-arylation of 3-trimethylsilylindazoles[J].Tetrahedron Lett.,2005,46(21):3 771-3 774.
  • 5LEBEDEV A Y,KHARTULYARI A S,VOSKOBOYNIKOV A Z.Synthesis of 1-aryl-1H-indazoles via palladium-catalyzed intramolecular amination of aryl halides[J].J.Org.Chem.,2005,70(2):596-602.
  • 6KINGSBURY W D,GYURIK R J,THEODORIDES V J,et al.Synthesis of 1-and 2-substituted indazoles as anthelmintic agentst[J].J.Med.Chem.,1976,19(6):839-840.
  • 7ROUSSEAU V,LINDWALL H G.Structure and ultraviolet absorption spectra of indazole,3-substituted indazole and some of their derivatives[J].J.Am.Chem.Soc.,1950,72(7):3 047-3 048.
  • 8CHRISTOPH R,VOLKER H.Simplification of the jacobson indazole synthesis[J].Synthesis,1972,(7):375-376.
  • 9GIOVANNI B P,BARBARA C,GIAMPIERO S,et al.A new synthetic approach to indazole synthesis[J].Synthesis,1997,(10):1 140-1 142.
  • 10DICARLO F J.Synethesis of oxindole[J].J.Am.Chem.Soc.,1944,66(8):1 420.

共引文献9

同被引文献5

引证文献1

广东化工
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部