虚实辨证推拿治疗小儿急性非细菌感染性腹泻的临床对照研究

Clinical Control Trial of Massage Therapy Based on Deficiency-Excess Syndrome Differentiation for Acute Non-bacterial Diarrhea in Children

【目的】观察虚实辨证推拿治疗小儿急性非感染性腹泻的临床疗效。【方法】将113例小儿急性非感染性腹泻患儿随机分为试验A组37例、试验B组38例及对照组38例。3组均给予基础治疗(包括喂养指导、预防脱水及纠正脱水),试验A组在基础治疗的同时给予内服固定处方中药汤剂,试验B组在A组的基础上配合虚证推拿法或实证推拿法,对照组在基础治疗的同时口服思密达。3组均以3 d为1个疗程,疗程结束后观察临床疗效。【结果】全分析集(full analysis set,FAS)和符合方案集(per protocol set,PPT)的分析结果一致,3组的疗效基本相当,组间比较差异均无统计学意义(P﹥0.05)。治疗期间3组病例均未见明显不良反应。【结论】基础治疗是治疗小儿急性非细菌感染性腹泻的关键,中药辨证施治能起到与思密达基本相同的作用,而虚实辨证推拿治疗并不能显著提高中药辨证治疗的疗效。

Objective To investigate the therapeutic effect of massage therapy based on deficiency-excess syndrome differentiation for acute non-bacterial diarrhea in children.Methods One hundred and thirteen children with acute non-bacterial diarrhea were allocated to treatment group A（N = 37）,treatment group B（N = 38） and control group（N = 38）.All of the three groups were given routine treatment including feeding instruction,dehydration prevention,and dehydration correction.In addition,treatment group A was given the decoction of the same herbal recipe,treatment group B was given massage therapy based on deficiency-excess syndrome differentiation,and the control group was given Smecta orally.The treatment covered 3 days,and the therapeutic effect was evaluated after treatment in the three groups.Results The therapeutic effect was similar in the three groups after evaluation by full analysis set（FAS） and per protocol set（PPT）,and the difference was insignificant among the three groups（P 0.05）.No obvious side reaction was found in the three groups during the treatment.Conclusion On the basis of routine treatment,herbal medicine based on syndrome differentiation has the same effect as Smecta,but massage therapy based on deficiency-excess syndrome differentiation has no effect on enhancing the therapeutic effect of herbal medicine for acute non-bacterial diarrhea in children.