鸦胆子油乳联合化疗方案治疗晚期结直肠癌临床疗效观察

目的观察鸦胆子油乳联合FOLFIRI方案化疗与单纯FOLFIRI方案化疗对晚期结直肠癌患者的疗效以及对生活质量的影响。方法将109例患有晚期结直肠癌患者随机分为两组:治疗组,在FOLFIRI化疗方案基础上加用鸦胆子油乳治疗;对照组,单纯接受FOLFIRI方案化疗。对109例患者追踪2个月,观察并比较患者的疗效、体力状况、生活质量、不良反应等方面的差异。结果在FOLFIRI方案化疗基础上加用鸦胆子油乳治疗后,患者经中医症候评定疗效与单纯FOLFIRI方案化疗相比差异具有统计学意义(P<0.05);在改善患者体力状况、生活质量方面均优于单纯FOLFIRI方案化疗(P<0.05);在化疗所引发的白细胞、血红蛋白和血小板降低等不良反应发生率方面低于单纯FOLFIRI方案化疗组(P<0.05)。结论鸦胆子油乳联合FOLFIRI方案化疗治疗晚期结直肠癌不仅可以起到化疗增效的作用,而且能够明显提高患者生活质量和体力状况,降低化疗引发的不良反应,这一联合治疗方案可以在临床治疗中推广。

Objective To observe the differences between FOLFIRI chemotherapy and Fructus Brucea Oil Emulsion combination with chemotherapy treatment for the advanced colorectal cancer （CRC） patients＇ therapeutic effect and the quality of life. Methods 109 cases advanced CRC patients were randomly divided into chemotherapy group and Fmctus Brucea Oil Emulsion combination with chemotherapy group. Chemotherapy group was treated with FOLFIRI scheme. The other group was treated with Fructus Brucea Oil Emulsion and FOLFIRI scheme, All patients were observed for two months and analyzed the differences in the therapeutic effect, body quality score, quality of life score and toxic effect. Results Fructus Brucea Oil Emulsion combination with FOLFIRI scheme is superior to FOLFIR1 scheme in the therapeutic effect and improvement of body quality score, quality of life score and the decrease of toxic effect （P〈0.05）. Conclusion Fructus Brucea Oil Emulsion combination with FOLFIRI scheme could increase the therapeutic effect, improve the life quality and body quality of the patients and decrease the incidence of toxic effect induced by chemotherapy.