埃索美拉唑联合莫沙必利治疗反流性食管炎的疗效观察

Effects of esomeprazole combined with mosapride in treatment of reflux esophagitis

目的:探讨埃索美拉唑联合莫沙必利治疗反流性食管炎的临床疗效。方法:将94例反流性食管炎患者随机分成3组,对照组Ⅰ、Ⅱ组分别单纯服用埃索美拉唑和莫沙必利,治疗组同时服用埃索美拉唑和莫沙必利,评价其疗效差异。结果:治疗前3组反流性食管炎患者的反酸、烧心、咽下困难以及胸骨后灼痛的症状积分比较差异无统计学意义(P>0.05),经过治疗4周后,症状积分均较治疗前显著降低(P<0.05),且治疗组明显低于对照组,差异有统计学意义(P<0.05)。治疗4周后,治疗组总有效率显著高于对照组(P<0.05),而其不良反应发生率明显低于对照组(P<0.05)。结论:埃索美拉唑与莫沙必利的联合应用具有协同作用,起效快、疗效好,不良反应少,安全可靠。

Objective. To investigate the effects of esomeprazole combined with mosapride in treat- ment of reflux esophagitis. Methods. Ninety-four cases of reflux esophagitis were randomly divided into three groups, patients in control group only received esomeprazole or mosapride treatment, while others received esomeprazole and mosapride treatment synchronously, and curative effects were compared among the three groups. Results; There were no significantly statistical difference in symptom scores of heart- burn, acid reflux, dysphagia and retrosternal burning pain among the three groups before treatment （P〉0.05）, but after 4 weeks of treatment, symptom scores significantly reduced in all groups （P〈0.05）, and the symptom scores and incidence of side effects of treatment group were both significantly lower than those in control group （P both 〈0.05）, but the total effective rate of the treatment group was significant- ly higher than that of the control group （P〈0.05）. Conclusion. Combined use of esomeprazole and mosa- pride is effective on reflux esophagitis showing advantages of few complications, safety and reliability and it is worthy to be popularized.