摘要
目的调查未接受高效抗反转录病毒治疗(highly active antiretroviral therapy,HAART)的HIV/AIDS患者血清隐球菌抗原的阳性率。方法回顾性调查我院感染科2012年1—9月住院的77例未接受HAART的HIV/AIDS患者外周血CD4+T淋巴细胞计数及血清隐球菌抗原阳性率,比较隐球菌抗原阳性患者与阴性患者的CD4+T淋巴细胞计数。结果 77例(男53例,女24例)中,血清隐球菌抗原阳性48例,阳性率为62.34%,阴性29例,阴性率为37.66%。其中,CD4+T淋巴细胞计数≤50个/mm3的患者血清隐球菌抗原阳性率为72.73%。血清隐球菌抗原阳性患者外周血CD4+T淋巴细胞计数显著低于阴性患者(P=0.022)。结论未接受HAART的外周血CD4+T淋巴细胞计数较低的HIV/AIDS患者血清隐球菌抗原阳性率高,血清隐球菌抗原阳性患者CD4+T淋巴细胞水平低于阴性患者(P<0.05)。
Objective To investigate the positive rates of serum cryptococcal antigen in HIV/AIDS patients without initiating highly active antiretroviral therapy （HAART）. Methods CD4＋ T lymphocyte counts and the positive rates of serum cryptococcal antigen of 77 HIV/AIDS patients without initiating HAART, who were hospitalized in the department of infectious diseases of our hospital from Jan. to Sept. 2012, were analyzed retrospectively. CD4＋ T lymphocyte counts were compared between serum cryptococ- cal antigen positive patients and negative patients. Results Of 77 HIV/AIDS patients （53 males and 24 females）, 48 （62.34%） were serum cryptococcal antigen positive, and 29 （37.66%） were serum cryptococcal antigen negative. The positive rate of serum crypto- coccal antigen was 72.73% in the patients with CD4＋ T lymphocyte count ≤ 50/mm3. CD4＋ T lymphocyte counts of the cryptococcal antigen positive patients were significantly lower than those of the negative patients （P=0.022）. Conclusions This study reveals a high prevalence of cryptococcal antigen in HIV/AIDS patients without receiving HAART whose CD4＋ T lymphocyte counts are lower. CD4＋ T lymphocyte counts of HIV/AIDS patients with serum eryptococcal antigen positive are significantly lower than those of HIV/ AIDS patients with serum cryptococcal antigen negative （P〈0.05）.
出处
《传染病信息》
2012年第6期353-355,384,共4页
Infectious Disease Information
基金
国家"十二五"科技重大专项(2012ZX10001-003-001)
2009郑州市科技攻关项目(N2008SP0138)
