期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

Wnt/β-catenin信号通路调控肝细胞生长及Galectin-3的重要作用

下载PDF
导出
摘要 最早的wnt基因是由Nusse等于1982年发现并报道，从鼠类乳腺癌病毒（MMTV）诱导的小鼠乳腺癌中克隆出的种原癌基因，当时被称为int-1基因。接下来的研究发现int-l基因与1973年Sharma报道的果蝇的无翅基因Wingless（wg）为同源基因，所以将两者合并命名为Wnt。后来运用PCR技术发现了大量Wnt家族成员，从线虫到脊椎动物的许多物种中均有Wnt基因家族成员的存在，人类基因组中已经发现和经试验证实共有19个wnt基因，果蝇中有7个。
作者 郭银燕 郑以山 杨永峰
机构地区 东南大学附属南京第二医院肝病科
出处 《肝脏》 2012年第12期894-896,共3页 Chinese Hepatology
关键词 WNT β-catenin GALECTIN-3 肝细胞生长 信号通路 wnt基因 小鼠乳腺癌 调控 家族成员
分类号 R575 [医药卫生—消化系统]
  • 相关文献

参考文献23

  • 1Nusae R,Varmus HE. Manytumors induced by the mouse mammary tumor virus contain a provirus intergrated in the same region of the host genome. Cell, 1982,31:99-109.
  • 2Yang-Snyder J, Miler JR, Brown JD, et al. Curt Biol, 1996,6 : 1302-1306.
  • 3何益,熊伍军,刘菲.Wnt信号转导通路与肝纤维化[J].国际消化病杂志,2008,28(1):57-59. 被引量：11
  • 4Monga SP, Pediaditakis P, Mule K, et al. Changes in Wnt beta-catenin pathway during regulated growth in ratliver egeneration. Hepatology, 2001,33 : 1098-1109.
  • 5Xinping T, Hua L, George K. Epidermal Growth Factor Receptor: A Novel Target of the Wnt/β-Catenin Pathway in Liver, Gastroenterology, 2005,129:285-302.
  • 6Thompson MD, Monga SP. Wnt/Beta-Catenin Signaling in Liver Health and Disease, Hepatology,2007,45 : 1298-1305.
  • 7Sodhi D, Micsenyi A, Bowen WC, et al. Morpholino oligonucleotide triggered beta catenin knockdown compromises normal liver regeneration. J Hepatol , 2005,43 : 132-141.
  • 8Myung SJ,Yoon JH,Gwak et al. Wnt signaling enhances the activation and survival of human hepatic stellate cells. FEBS Lett,2007,581:2954-2958.
  • 9Shackel NA, McGuinness PH, Abbott CA, et al. Identification of novel molecules and pathogenic pathways in primary biliary cirrhosis:cDNA aray analysis of intrahepatic differential gene expression. Gut, 2001,49 : 565-576.
  • 10Shimura T, Takenaka Y, Tsutsumi S, et al. Galectin-3 a novel binding partner of catenin. Cancer Res, 2004,64:6363-6367.

二级参考文献15

  • 1Bejsovec A. Wnt pathway activation: new relations and locations. Cell, 2005, 120: 11-14.
  • 2Veeman MT, Axelrod JD, Moon RT. A second canon: functions and mechanisms of beta catenin independent Wnt signaling. Dev Cell, 2003, 5: 367-377.
  • 3Surendran K, McCaul SP, Simon TC. A role for Wnt 4 in renal fibrosis. Am J Physiol Renal Physiol, 2002, 282: 431-441.
  • 4Surendran K, Schiavi S, Hruska KA. Wnt dependent betacatenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal fibrosis. J Am Soc Nephrol, 2005, 16:2373-2384.
  • 5Chilosi M, Poletti V, Zamo A, et al. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis. Am J Pathol, 2003, 162.- 1495-1502.
  • 6Sato M. Upregulation of the Wnt/beta-catenin pathway induced by transforming growth factor-beta in hypertrophic scars and keloids. Aeta Derm Venereol, 2006, 86: 300- 307.
  • 7Zeng G, Awan F, Otruba W, et al. Wnt'er in liver: expression of Wnt and frizzled genes in mouse. Hepatology, 2007, 45: 195-204.
  • 8Young CS, Kitamura M, Hardy S, et al. Wnt-1 induces growth, cytosolic β- catenin, and Tcf/Lef transcriptional activation in Rat 1 fibroblasts. Mol Cell Biol, 1998, 18:2474-2485.
  • 9Labbe E, I.etamendia A, Attisano L. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci USA, 2000, 97: 8358-8363.
  • 10Oloumi A, McPhee T, Dedhar S. Regulation of E-cadherin expression and beta catenin/Tcf transcriptional activity by the integrin-linked kinase. Biochim Biophys Acta, 2004, 1691 : 1-15.

共引文献10

肝脏
2012年 第12期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部