决定肺癌增长速度主要因素的探讨

AN EXPLORATION OF THE ESSENTIAL FACTORS DETERMINING THE GROWTH RATE OF PRIMARY LUNG CANCER

本文根据132例原发性周围型肺癌增长速度的X线研究,发现组织类型是决定各型肺癌间增长速度不同的主要因素,而性别、年龄、发病部位、肿块大小、坏死等因素对其影响不大。通过动物实验证实,同一组织类型肺癌间增长速度不同是个体差异影响细胞分化不同所决定的。而同一个体肺癌在其增长过程中的各阶段增长速度不同,即呈阶梯式增长,又可能与个体的免疫、神经内分泌功能变动有关。

The X-ray findings in ] 32 cases of the peripheral type of primary lung cancer were studied. It was found that the doubling time (Dt) in small cell lung cancer was the shortest of all, and that in the squamous cell cancer and adeno-carcinoma, it was longer than that in the remaining types. No change caused by difference in sex, and age of the patient, the location, size and necrosis of the lesion was observed. It was concluded that the cancer histotype is the essential factor in determination of the growth rate of lung cancer, while any difference observed under the same conditions of the tumor-carrying patients are due to individual characteristics including immunity and neuroendocrinological state of the patients.