铝碳酸镁联合莫沙必利治疗胆汁返流性胃炎的临床研究

Clinieal efficacy of hydrotaleite comhined with mosapride in treating bile reflux gastritis

目的探讨铝碳酸镁联合莫沙必利治疗胆汁返流性胃炎（BRG）的疗效。方法病例来源我院门诊103例胆汁返流性胃炎患者，分为治疗组53例，铝碳酸镁咀嚼服用1克，餐前1小时前服，3次／日，对照组50组，法莫替丁20mg口服，2次／日；两组同时给予莫沙必利5mg口服，3次／日。治疗4周后评估临床效果。结果治疗组总有效率96．23％，对照组总有效率80．00％，治疗组总有效率显著高于对照组，差异有显著性（P〈0．05）。结论铝碳酸镁联合莫沙必利治BRG的疗效好，副作用少。

Objective To investigate the clinical efficacy of treating bile reflux gastritis （BRG） using hy- drotalcite combined with mosapride. Methods 103 patients with gastric ulcer in our hospital were divided into treatment group with 53 cases, chew taking hydrotalcite lg 1 hour before meals, 3 times/day; and control group with 50 cases, taking Famotidine 20 mg 2 times/day. Two groups took mosapride 5 mg 3 times/day. We evaluated the clinical effects after 4 weeks of treatment. Results The total effective rate of treatment group was 96.23%, higher than that of the control group （80.00%） .The difference was statistically significant （P〈0.05）, with few side effects. Conclusions Treating bile reflux gastritis with hydrotalcite and mosapride has better effect and fewer sideeffects.