以取代氨基硫脲为手臂的新型脱氧胆酸类分子钳的微波合成

Microwave-Assisted Synthesis of Novel Molecular Tweezers Based on Deoxycholic Acid with Arm of Substituted Thiosemicarbazides

在微波辐射条件下,以脱氧胆酸甲酯为隔离基,通过三光气桥连取代氨基硫脲为手臂,以良好的产率合成了10个新型脱氧胆酸分子钳,其结构均经1H NMR,IR,MS及元素分析确证.微波法具有反应时间短,产率高,对环境友好等优点.利用差紫外可见光光度滴定法测试了主体化合物对Cl-,Br-,I-,NO-3等阴离子的识别作用.实验结果表明,主体对阴离子有良好的识别性能.

Ten new molecular tweezers based on deoxycholic acid were synthesized in good yields by using deoxycholic acid methyl ester as spacer to bridge different substituted thiosemicarbazides via triphosgene under microwave irradiation. Their structures were charactetized by 1H NMR, IR, MS techniques and elemental analysis. The microwave method has distinct advantages such as short reaction time, high yields and eco-friendly to the environment. The recognition properties of these molecular tweezers for CI-, Br-, I-, NO3 anions were investigated by UV-vis spectra titration. The result indicated that this type of molecular tweezers has good binding properties for anions.