摘要
通过药效团整合策略将天然抗肿瘤活性木脂素山荷叶素与组蛋白去乙酰化酶抑制剂的药效团长链异羟肟酸或长链硫醇进行拼合,得到了7个未见文献报道的山荷叶素衍生物,通过核磁共振氢谱、碳谱、高分辨质谱等方法进行了结构表征.并采用了噻唑蓝法(MTT)法对这些化合物的体外抑制肿瘤细胞增殖活性进行了测试,异羟肟酸类衍生物具有较强的活性.
Seven novel diphyllin derivatives have been synthesized by incorporating histone deacetylase inhibitory functional groups into diphyllin. The structures were confirmed by 1H NMR, 13C NMR and HRMS. Their antiproliferative activity against three human cancer cell lines was investigated by methyl thiazolyl tetrazoliym （MTT） assay.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2013年第1期169-173,共5页
Chinese Journal of Organic Chemistry
基金
江苏省自然科学基金(No.BK2011390)
江苏省高校优势学科(PAPD)资助项目~~
