2,3,8,9-四氢吡啶并[2,3-d:6,5-d']二嘧啶-4,6-二酮衍生物的合成

Synthesis of 2,3,8,9-Tetrahydropyrido[2,3-d:6,5-d']dipyrimidine-4,6-diones

以丙二腈、原羧酸三乙酯、吡啶为起始原料经环化、氨解,然后与酮在甲醇钠催化下反应得到了2,3,8,9-四氢吡啶并[2,3-d:6,5-d']二嘧啶-4,6-二酮衍生物.目标产物的结构经IR,NMR,ESI和元素分析确证.

2,3,8,9-Tetrahydropyrido[2,3-d：6,5-d＇]dipyrimidine-4,6-diones were synthesized by using malononitrile, or- tho-triethyl and pyridine as starting materials in three steps reaction including cyclization, ammonolysis and reaction with ke- tones under the catalysis of sodium methoxide. The structures of the products were confirmed by NMR, IR, ESI and elemental analysis.