太赫兹技术对头孢菌素类抗生素的研究

Study on Cephalosporins with Terahertz Time-Domain Spectroscopy Technique

太赫兹时域光谱(THz-TDS)技术对物质进行识别和定量分析是太赫兹应用领域的一个研究热点。文章报道了14种头孢类抗生素纯品在0.2～2.6THz波段的共振吸收谱和折射率谱,其中8种特征吸收峰明显。没有明显特征吸收峰的抗生素样品在该波段的折射率谱也有较为明显差异。这些结果是利用太赫兹时域光谱技术鉴别抗生素品种的依据。利用纯品太赫兹吸收谱,对两个不同厂家生产的头孢克肟药品进行了主成分定量评估,分别得到了头孢克肟在药品中的含量,它们与药品包装上标定含量的相对误差分别为9.38%和0.92%。证明了太赫兹技术在药品检测中的可靠性和良好的应用前景。

Terahertz Time-Domain Spectroscopy （THz-TDS） technique has a wide range of applications in substances identifica-tion and quantitative analysis. In the present paper, we report absorption spectra and index of refraction of 14 kinds of pure cephalosporins in 0. 2～2. 6 THz, in which eight kinds have apparent absorption peaks, while the others have different index of refraction. Based on these results, different kinds of antibiotics can be identified. Besides, according to THz absorption spectra of both pure sample and real pills we calculated the contents of cefixime in the two pills produced by two manufacturers. Com- pared with the contents marked on the package, relative errors are 9. 38% and 0. 92%, respectively. The results manifest that THz-TDS technique is reliable and promising in medicine detection.