卵巢癌患者手术前后血清HE4、CA125和SIL-2R检测的临床意义

Clinical Significance of Measurement the Changes of Serum HE4,CA125 and SIL-2R Levels Both Before and After Operation in Patients with Ovarian Cancer

目的:探讨卵巢癌患者手术治疗前后血清HE4、CA125和SIL-2R水平的变化及临床意义。方法:应用放射免疫分析、酶联法对33例卵巢癌患者进行治疗前后血清HE4、CA125和SIL-2R检测,并与35名正常健康人作比较。结果:卵巢癌患者手术前血清HE4、CA125和SIL-2R水平非常显著地高于正常人组(P<0.01)。手术治疗3个月后则与正常人组比较无显著性差异(P>0.05)。血清HE4水平与CA125、SIL-2R水平呈显著正相关(r=0.5784、0.6122,P<0.01)。结论:检测卵巢癌患者手术治疗前后血清HE4、CA125和SIL-2R水平的变化与该病的发生和发展密切相关。

Objective To explore the clinical significance of measurement the changes of serum HEA, CA125 and SIL - 2R lev- els both before and after operation in patients with ovarian cancer. Methods Serum CA125 （with RIA）, serum HE4, SIL-2R（with ELISA） levels were measured in 33 patients with ovarian cancer both before and after operation as well as in 35 normal healthy con- trols. Results Before operation serum HE4, CA125 and SIL - 2R in patients with ovarian cancer were significantly higher than those in controls （ P 〈 0.01 ）. 3 months after operation the levels dropped markedly to normal in comparison with controls （P 〉 0.05）. Serum HE4 Level was positively correlated with serum CA125, SIL - 2R levels （ r = 0. 5784, 0.6122, P 〈 0. O1 ）. Conclusion The serum HE4, CA125 and SIL-2R levels both before and after operation in patients with ovarian cancer closely related to the progress of the diseases.