利培酮与奥氮平对男性精神分裂症患者性激素水平的影响

Study on Impact of Risperidone and Olanzapine on Sexual Hormones in Treatment of Male Schizophrenia

目的:探讨第2代抗精神分裂症药对男性精神分裂症患者血清睾酮、雌二醇、催乳素水平的影响。方法:将85例男性精神分裂症患者随机分成利培酮组42例和奥氮平组43例,分别给予利培酮和奥氮平治疗8周后,应用电化学发光法检测治疗前后血清睾酮、雌二醇、催乳素水平,并与60例健康对照者进行比较。结果:治疗后血清睾酮、雌二醇、催乳素水平均高于治疗前(P<0.05),利培酮所引起的浓度变化更为明显,差异有统计学意义(P<0.05)。结论:利培酮与奥氮平对男性精神分裂症患者性激素水平产生不同程度的影响,但影响因素较多。

Objective To explore the serum levels of testosterone, estradiol and prolactin in the male patients with schizophrenia and the effects of second generation antipsychotics drugs on them. Methods All 85 male patients with schizophrenia were randomly assigned to risperidone group （42 cases） treated with risperidone and olanzapine group （43 cases） treated with olanzapine for 8 weeks. The electro chemiluminescence immune assay（ECLIA） was used to detect serum testosterone, estradiol and prolactin levels respectively before and after treatment, and with 60 healthy controls for comparison. Results After treatment, the serum levels of testosterone,estradiol and prolactin were higher than before treatment （P 〈 O. 05）. But in risperidone group, the levels changed distinctly, it had statistically significant difference （P 〈 0.05 ）. Conclusion Risperidone and olanzapine had different impact of level on sexual hormones in treatment of male schizophrenia, but it had a lot of influential factors.