立止血联用兰索拉唑治疗呼吸衰竭并发上消化道出血

Clinical curative effect of reptilase combined with lansoprazole for respiratory failure with upper digestive tract hemorrhage

目的探讨立止血联用兰索拉唑对呼吸衰竭并发上消化道出血的治疗效果。方法 68例呼吸衰竭并发上消化道出血患者,随机分为观察组(立止血+兰索拉唑,n=36)和对照组(止血敏+兰索拉唑,n=32),比较两组的疗效情况。结果观察组、对照组总有效率分别为83.33%(30/36)、56.25%(18/32),观察组优于对照组,差异具有显著性(P<0.05);两组治疗72 h后胃液pH值均有改善,但观察组优于对照组,差异具有显著性(P<0.05)。结论立止血联用兰索拉唑治疗呼吸衰竭并发上消化道出血疗效显著,用药方便、安全,值得临床推广。

【Objective】 To study the effects of reptilase combined with lansoprazole treating respiratory failure with upper digestive tract hemorrhage.【Methods】 With the random blind method,68 patients of upper digestive tract hemorrhage complicatory with respiratory failure were divided into two groups.The control group（n =32） was treated with conventional therapy,dicynone and lansoprazole.The observational group（n =36） was treated with conventional therapy,reptilase and lansoprazole.The therapeutic efficacy and the pH value of gastric juice were detected,respectively at 72 hour after therapy.【Results】 Effective rates were as follows： The observational group 83.33%（30/36）,the control group 56.25%（18/32）,the difference（P 0.05） was significant.The pH value of gastric juice in both two groups showed obvious improvements but in observational group they were better（P 0.05）.【Conclusions】 This treating method has following advantages： Significant therapeutic efficacy,more convenient and safe.So it is worth spreading in clinical application.