基于聚类分析的月经过少中医证候研究

TCM syndromes of hypomenorrhea studied based on clustering analysis

目的探讨月经过少的证候分布规律。方法制定"中医证候临床调查表",对符合纳入标准的月经过少患者进行中医证候的调查并填写调查表;建立SPSS13.0统计数据库,将159例月经过少患者的调查资料输入数据库,运用聚类分析方法进行数据分析,结合临床确定其证候分布特点。结果聚类分析结果聚为5类,分别为肾虚血瘀证(30.2%)、肾虚肝郁证(28.3%)、气滞血瘀证(17%)、肝郁脾虚证(13.2%)、脾肾阳虚证(11.3%),初步确定了各证型的特点。结论月经过少患者中证候分布特点为肾虚血瘀证>肾虚肝郁证>气滞血瘀证>肝郁脾虚证>脾肾阳虚证,病性以虚实夹杂为多见,本研究为月经过少的进一步规范化辨证论治提供了一定依据。

Objective To discuss the syndrome distribution laws of hypomenorrhea. Methods A cli^fical questionnaire of TCM syndromes was established, and the patients according with the enclose standard were given the survey of TCM syndromes and were asked to fill the questionnaire. Tile database of SPSS13.0 was set up and the data from 159 patients were input in. The data was analyzed and syndrome distribution laws were determined by using clustering analysis combining clinical materials. Results There were 5 syndromes clustered including syndrome of kidney deficiency and blood stasis （30.2%） , syndrome of kidney deficiency and liver depression （28.3%） , syndrome of qi stagnation and blood stasis （ 17% ）, syndrome of liver depression and spleen deficiency （ 13.2% ） and syndrome oi spleen-kidney yang deficiency （11.3%）. The characteristic of all syndromes were initially determined. Conclusion The distribution characteristics of TCM syndromes showed as follows： syndrome of kidney deficiency and blood stasis 〉 syndrome of kidney deficiency and liver depression 〉 syndrome of qi stagnation and blood stasis 〉 syndrome of liver depression and spleen deficiency 〉 syndrome of spleen- kidney yang deficiency in the patients with hypomenorrhea. This study provides some evidences for further standardized syndrome differentiation and treatment of hypomenorrhea.