血浆儿茶酚胺水平对脓毒症患者心功能不全的影响

The Effect of Catecholamine on Cardiac Dysfunction in Sepsis Patients

脓毒症相关的心功能不全的病理生理学机制是比较复杂的．近年来被认为涉及多个机制。脓毒症时儿茶酚胺的过度产生和外源性儿茶酚胺的输注可能对脓毒症相关的心功能不全的发生有关。高水平的血浆儿茶酚胺直接对心脏有毒性作用，其中涉及儿茶酚胺诱导的心肌毒性的病理生理学机制涉及炎症，氧化应激．导致心肌顿抑．凋亡、坏死的异常钙转运。

The pathophysiology of septic heart failure is complex and currently believed to involve several mechanisms. Excessive catecholamine production and exogenous administration of catecholamines may relevantly contribute to the development of heart failure and cardiovascular collapse in patients suffering from septic shock. The pathophysiologic mechanisms involved in catecholamine-induced cardiomyocyte toxicity may involve a combination of inflammation, oxidative stress, and abnormal calcium handling resulting in myocardial stunning, apoptosis and necrosis.