苏木对红花中羟基红花黄色素A的药代动力学影响

Pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A in Carthami Flos

目的:研究苏木对红花中羟基红花黄色素A(HSYA)的药代动力学的影响。方法:RP-HPLC测定红花单煎液和红花-苏木配伍液灌胃后正常大鼠血浆中HSYA的血药浓度,DAS 2.0药动学软件计算药动学参数。结果:红花单独给药、红花-苏木配伍给药,HSYA在体内代谢动力学模型均为二室开放模型;配伍后,HSYA的分布半衰期t1/2α、吸收半衰期t1/2Ka、表观分布容积VL/F显著减小,达峰时间tmax有所提前。结论:苏木可加快HSYA在体内的吸收和分布,加快HSYA在体内的代谢过程,减少HSYA在体内的蓄积。

Objective： To investigate the pharmacokinetic effect of Sappan Lignum on hydroxysafflor yellow A （HSYA） in Carthami Flos. Method： Concentration of HSYA in rat plasma was detected by RP-HPLC after rats were orally administered with ex- tracts of Carthami Flos or Carthami Flos combined with Sappan Lignum. Pharmacokinetic parameters were calculated by DAS 2. 0 phar- macokinetic software. Result： In vivo pharmacokinetic models of HSYA were two-compartment open models in both of the Carthami Flos group and the Carthami Flos combined with Sappan Lignum group. After compatibility, HSYA showed a significant lower in appar- ent volumes of distribution of t1/2Ka, t1/2a and V1/F, with slight advance in Tmax. Conclusion： Sappan Lignum can accelerate absorp- tion, distribution and metabolic process of HSYA in vivo and reduce its accumulation in vivo.