枣仁安神胶囊治疗老年性失眠症的疗效及血液流变学研究

Study on efficacy of zaoren anshen capsules in treating senile insomnia and changes in its hemorheology

目的:观察枣仁安神胶囊治疗老年性失眠症的疗效及血液流变学变化。方法:用随机方法将120例老年失眠症病人分成枣仁安神胶囊组5片/晚与阿普唑仑组0.8 mg/晚各60例进行治疗对照观察,并用匹兹堡睡眠质量指数(PSQI)量表分别于治疗前和治疗1,4周评估临床疗效。结果:枣仁安神胶囊组治疗4周后的PSQI分(5.91±1.37)分低于治疗前(13.49±3.87)分,差异具有高度统计学意义(P<0.01);阿普唑仑组治疗4周后的PSQI分低于治疗前,差异也具有高度统计学意义(P<0.01);除枣仁安神胶囊组治疗1周后的PSQI分高于阿普唑仑组(P<0.05)外,治疗前和治疗4周枣仁安神胶囊组和阿普唑仑组组间同期比较差异无统计学意义;枣仁安神胶囊组血液流变学参数全血黏度比高切、全血黏度比低切、全血高切还原黏度治疗前后差异有高度统计学意义(P<0.01),血浆黏度治疗前后差异有统计学意义(P<0.05);枣仁安神胶囊不良反应比阿普唑仑要小。结论:枣仁安神胶囊的功效与阿普唑仑无显著差异,副反应少,适合于老年失眠症患者,可改善老年失眠症患者的某些血液流变学指标,具有良好的活血化瘀作用。

Objective： To observe the effect of Zaoren Anshen capsules in treating senile insomnia and changes in its hemorhe- ology. Method： A total of 120 patients with senile insomnia were randomly divided into the Zaoren Anshen capsules group （five cap- sules, n = 60） and the Alprazolam group （0.8 mg, n = 60 ） for treatment and control observation. Pittsburgh sleep quality index （PSQI） was used for evaluating clinical efficacy in the first and fourth week before and after treatment. Result： The Zaoren Anshen capsules group had lower higher scores in PSQI （5.91 ± 1.37 ） than that before treatment （ 13.49 ± 3.87）, with great statistical signif- icant in difference （P 〈 0.01 ）. The alprazolam group had lower higher scores in PSQI than that before treatment, with great statistical significant in difference （ P 〈 0.01 ）. apart from higher PSQI scores in the Zaoren Anshen capsules group than that of the Alprazolam group after treatment for one week （ P 〈 0.05 ）, the comparison between the Zaoren Anshen capsules group and the alprazolam group before and after treatment for four weeks showed no statistical significance. As for hemorheological parameters, the difference in the whole blood viscosity （including high-shear, middle-shear and low-shear） of patients in the Zaoren Anshen capsules showed great sta- tistical significance before and after treatment （ P 〈 0.01 ） , and so did the plasma viscosity （ P 〈 0.05 ）. Zaoren Anshen capsules showed less adverse reactions than alprazolam. Conclusion： Zaoren Anshen capsules have similar effect in treating senile insomnia with alprazolam, with less adverse reactions. They are so suitable for patients with senile insomnia that they can improve hemorheologi- cal indicators of patients with senile insomnia and have good effect in promoting circulation and removing stasis.