极低出生体重儿支气管肺发育不良的高危因素分析

Analysis on high risk factors of bronchopulmonary dysplasia in very low birth weight infants

目的:探讨极低出生体重儿发生支气管肺发育不良(Bronchopulmonary Dysplasia,BPD)的临床高危因素。方法:回顾性分析NICU收治的极低出生体重儿199例患儿的临床资料,根据是否发生BPD分为BPD组和非BPD组,分析BPD发生的可能危险因素。结果:199例低出生体重儿中有48例发生BPD,发病率为24.1%。与非BPD患儿组相比,BPD组患儿在机械通气时间、总吸氧时间、吸氧浓度>40%时间、宫内感染、合并动脉导管未闭、院内感染等方面比较差异有统计学意义(P<0.05),Logistic回归分析结果显示机械通气时间、宫内感染、吸氧浓度>40%时间为疾病发生的危险因素。结论:预防宫内感染可降低BPD的发生率,长时间机械通气及高浓度吸氧为BPD发生的高危因素。

Objective：To explore the clinical high risk factors of bronchopulmonary dysplasia（BPD） in very low birth weight infants.Methods：The clinical data of 199 very low birth weight infants who were treated in NICU of the hospital were analyzed retrospectively,then they were divided into BPD group and non-BPD group;the probable risk factors of BPD were analyzed.Results：Among 199 very low birth weight infants,48 infants were diagnosed as BPD,the morbidity was 24.1%.There were statistically significant differences in the time of mechanical ventilation,the time of oxygen inhalation,the time of oxygen inhalation with oxygen concentration40%,intrauterine infection,combined with patent ductus arteriosus,and nosocomial infection between BPD group and non-BPD group（P0.05）;the results of logistic regression analysis showed that the time of mechanical ventilation,intrauterine infection,and the time of oxygen inhalation with oxygen concentration40% were the risk factors of BPD.Conclusion：Preventing intrauterine infection can reduce the morbidity of BPD,mechanical ventilation for a long time and oxygen inhalation with high oxygen concentration are high risk factors of BPD.