摘要
定位于人类等20号染色体短臂(20p13)上的ADAM33基因是解整合素-金属蛋白酶超家族中的一员。因ADAM33基因同样具有解整合素结构域和金属蛋白酶结构域,故称为解整合素-金属蛋白酶。自ADAM33基因被确定为哮喘的候选基因以来,ADAM33基因与不同种族及区域人群哮喘发病的相关性成为研究热点。现就ADAM33基因的几个重要位点在不同区域或种族中与哮喘的关联性研究予以综述。
Located in the human chromosome 20 short arm（ 20p13 ）, ADAM33 gene is a member of the family of disintegrin-metalloproteinase. For ADAM33 gene has both the disintegrin structural domain and the metalloproteinase structural domain, it is called a disintegrin-metalloproteinase. Since ADAM33 gene is deter- mined to be the asthma candidate gene, the correlation between ADAM33 gene and asthma incidence of dif- ferent racial and area populations has become one of the hot research spots. Here is to make a review on the correlation between several important sites of ADAM33 gene and asthma in different areas or races.
出处
《医学综述》
2013年第1期11-13,共3页
Medical Recapitulate
基金
国家自然科学基金(81160004)
