谷胱甘肽硫转移酶基因多态性与疾病关系的研究进展

Research Progress of Correlation between Diseases and Glutathione S-transferases Gene Polymorphism

谷胱甘肽硫转移酶(GSTs)由谷胱甘肽与亲电子物组成,大多数可与蛋白质或DNA发生反应。某些情况下(如在卤化物溶剂中),谷胱甘肽的结合物可以导致毒性及突变物增加。GSTs属于Ⅱ相抗氧化酶家族,是一种具有细胞解毒作用的蛋白质。目前大多采用的分类方法主要是根据GSTs亚基N末端氨基酸序列的同源性,考虑到各种GSTs的底物特异性、免疫反应性和对不同抑制剂的敏感性,将哺乳动物的GSTs分为GSTM1、GSTM3、GSTP1和GSTT1。现就GSTs基因多态性与其涉及的疾病予以概述。

Glutathione S-transferases （GSTs）is consisted of glutathione and electrophilie substance, most of which can act with protein and DNA. In some cases（ such as halogenated solvent） , glutathione conjugation may cause toxicity and increased mutation. GSTs belong to Phase II antioxidant enzyme family, and has anti- dotal function. At present, most classification methods are based on the homology of GSTs subunit N terminal amino acid sequence, zymolyte specificity, immune response and sensitivity to different inhibitors of GSTs. Mammalian GSTs are classified as GSTM1, GSTM3, CSTPland GSTT1. Here is to make a review on GSTs gene polymorphism and the related diseases.