新型微管结合蛋白在肿瘤发生与发展中的研究进展

Research Progress of the NuSAP in Tumor Development

新型微管结合蛋白(NuSAP)是一种重要的有丝分裂调节蛋白,在细胞分裂间期定位于核仁,在有丝分裂期与纺锤体的微管共同定位于胞质。NuSAP磷酸化和去磷酸化可动态调节其在细胞内功能。越来越多的研究表明,NuSAP选择性地在增殖性细胞中表达,其不仅参与纺锤体的稳定组装,而且与肿瘤组织的血管形成、增殖和侵袭有一定的相关性。随着分子生物学的发展,NuSAP有望成为新的肿瘤生物标志物和临床治疗的靶点,为肿瘤的早期诊断、临床治疗和预后提供新的方向。

The nucleolar spindle-associated protein （ NuSAP ） is a kind of important mitotic regulatory protein,located in the nucleolus during the period between cell division, co-localized with spindle micmtubule in the cytoplasm during the mitosis. The function of NuSAP in cells is adjusted dynamically through phospho- rylation and dephosphorylation. A growing number of studies have shown that NuSAP is a protein that is se- lectively expressed in proliferating cells, which is involved not only in the stability of the spindle assembly, but also in the formation, proliferation and invasion of the blood vessels in the tumor tissues. With the devel- opment of molecular biology, NuSAP is expected to become a new tumor biomarker and the target of the clini- cal therapy, which provides a new direction of the early diagnosis, clinical therapy and prognosis of cancers.