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HELLP综合征的研究进展 被引量:6

Research Progress in HELLP Syndrome
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摘要 HELLP综合征是妊娠期高血压疾病的严重并发症,常危及母婴生命,是导致孕产妇及围生儿死亡的原因之一。近年来,国内外学者对其发病机制进行了大量研究,有母胎免疫失衡,血小板聚集与消耗,血管内皮功能障碍及先天性固有脂肪酸氧化失调等学说,但其发病机制目前尚未阐明,可能是子痫前期或子痫的严重并发症,也可能是一种独立的疾病。 HELLP syndrome is a serious life-threatening complication of hypertensive disorders in preg- nancy, which is one of the main causes of maternal and perinatal mortality. In recent years, domestic and for- cign scholars have done a lot of studies about its pathogenesis, such as immune imbalance, platelet aggregation and consumption, endothelial dysfunction, congenital disorder of oxidation of fatty acid, but its pathogenesis is still not clarified. It may be an independent disease or aserious complication of preeclampsia or eclampsia.
出处 《医学综述》 2013年第1期123-126,共4页 Medical Recapitulate
关键词 HELLP综合征 人类白细胞抗原G 凝血酶敏感蛋白1 长链L-3-羟酰CoA脱氢酶 瘦素 HELLP syndrome Human leukocyte antigen-G Thrombospondin 1 Long-chain 3- hydroxyacyl-CoA dehydrogenase Leptin
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参考文献22

  • 1Kirkpatrick CA. The HELLP syndrome [ J ]. Acta Clin Belgt,2010, 65(2) :91-97.
  • 2Shankarkumar U, Sbankarkumar A, Chedda Z, et al. Role of 14-bp deletion/insertion polymorphism in exon 8 of the HLA-G gene in recurrent spontaneous abortion patients [ J ]. J Hum Reprod Sei, 2011,4(3) :143-146.
  • 3Ristich V, Liang S, Zhang W, et al. Tolerization of dendritic ceils by HLA-G[J]. Eur J Immunol,2005,35(4) :1133-1142.
  • 4Jin Y,Wang X,Xiao Y,et al. The role of TSP-1 on decidual macro- phages involved in the susceptibility to unexplained recurrent spon- taneous abortion [ J]. Am J Reprod Immunol, 2009, 61 ( 3 ) : 253 -260.
  • 5Stenczer B, Molvarec A, Szab6 G, et al. Circulating levels of throm- bospondin-1 are decreased in HELLP syndrome[ J]. Thromb Res, 2012,129(4) :470-473.
  • 6Spiekerkoetter U, Wood PA. Mitochondrial fatty acid oxidation dis- orders : pathophysiological studies in mouse models [ J ]. J Inherit Metab Dis ,2010,33 (5) :539-546.
  • 7Oprescu AI, Bikopoulos G, Nanssan A, et al. Free fatty acid-in- duced reduction in glucose-stimulated insulin secretion: evidence for a role of oxidative stress in vitro and in vivo [ J ]. Diabetes, 2007,56 ( 12 ) : 2927-2937.
  • 8Artwohl M, Roden M, Waldhusl W, et al. Free fatty acids trigger apoptosis and inhibit cell cycle progression in human vascular en- dothelial cells[ J]. FASEB J ,2004,18 ( 1 ) : i46-148.
  • 9Spiekerkoetter U. Mitochondrial fatty acid oxidation disorders:clin- ical presentation of long-chain fatty acid oxidation defects before and after newborn screening [ J ]. J Inherit Metab Dis, 2010,33 (5) :527-532.
  • 10LamireauD, Feghali H, Redonnet-Vernhet I, et al. Acute fatty liver in pregnancy:revealing fetal fatty acid oxidation disorders [ J ]. Arch Pediatr,2012,19(3) :277-281.

同被引文献36

  • 1曹泽毅.中华妇产科学[M].2版.北京:人民卫生出版社,2000:43.
  • 2乐杰,谢幸,等主编.妇产科学[M].第7版.北京:人民卫生出版社,2009.241.
  • 3陈灏珠,林果为,王吉耀.实用内科学[M].第14版.北京:人民卫生出版社,2013,2019-2024.
  • 4Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: a severe consequence of hypertension in pregnancy. Am J Obstet Gynecol, 1982, 142 (2) : 159-167.
  • 5Peng WX, Nakaii M, Matsushima T, et al. Atypical ease of reversible posterior leucoencephalopathy syndrome associated with puerperal HELLP syndrome. Arch Gyneeol Obstet, 2008, 278(3) : 269-271.
  • 6Vijayalakshmi B, Sethna F, Manford M, et al. Posterior re- versible encephalopathy syndrome in a patient with HELLP syndrome complicating a triploid pregnancy. J Matern Fetal Neonatal Med, 2010, 23 (8): 938-943.
  • 7Paul BS, Juneja SK, Paul G, et al. Spectrum of neurologi- cal complications in HELLP syndrome. Neurology India, 2013, 61(5): 467-471.
  • 8Schwarts RB, Feske SK, Polak JF, et al. Preeclampsiaeclamp- sia: clinical and neuroradiographie correlates and insights into the pathogenesis of hypertensive encephalopathy. Radiology, 2000, 217(2) : 371-376.
  • 9Jensen D, Duffin J, Lam YM, et al. Phy siolog ical mecha- nisms of hyperventilation dur ing human pregnancy. Respir Physiol Neuro biol, 2008 , 161 ( 1 ) : 76-86.
  • 10Sibai BM.Diagnosis,controversies,and management of the syndrome of hemolysiss,elevated liver enzymes,and low platelet count[J].Obstet Gynecol,2004,103(5):981.

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