可逆性后部脑病综合征的研究进展

Research Progress of Reversible Posterior Encephalopathy Syndrome

可逆性后部脑病综合征是近年来临床发现的一种与大脑后部白质病变相关的综合征,由多种病因引发,发病机制尚不明确。常见临床症状为头痛、恶心、呕吐、抽搐、视觉障碍及精神状态改变等。特征性神经影像学异常通常见于顶-枕叶的白质,CT或MRI显示双侧大脑后部为主的对称性片状脑水肿。及时正确地治疗可使临床症状和影像学改变完全逆转,故早期正确诊断和治疗十分重要。

Posterior reversible encephalopathy syndrome has been recently clinical distinguished with a group of signs and symptoms mainly associated with posterior cerebral white matter lesions, but the pathogenesis is still unknown with its diverse causes. The clinical presentation encompasses headache, nausea and emesis, sei- zures, visual disturbances, altered sensorium, and occasionally focal neurological deficit. Characteristic neuroim- aging abnormalities are often observed in the parieto-occipital lobe white matter, CT or MRI shows the mainly- rear bilateral symmetrical cerebral edema. Timely and proper treatment can make the clinical symptoms and neu- roimaging changes completely reversed,therefore early diagnosis and treatment are very important.