N端脑钠肽前体与维持性血液透析患者心血管疾病关系的研究进展

Research Progress of Relationship between N-terminal Pro-brain Natriuretic Peptide Level and Cardiovascular Diseases of Maintenance Hemodialysis Patients

心血管疾病在维持性血液透析(MHD)患者中发生率较高,是其主要死因。N端脑钠肽前体(NT-proBNP)是由心室肌细胞合成和分泌的肽类激素,可以反映体内心肌细胞受到的容量负荷和压力负荷的大小,已广泛应用于正常人群的心血管疾病的诊断、治疗及预后评价。近年来大量研究证明,NT-proBNP也可作为监测MHD患者心血管疾病的重要生物学标志,其浓度对早期评判MHD患者心脏结构和功能异常、预测心血管事件发生及死亡、评估容量负荷等具有重要价值。

Studies demonstrated that cardiovascular diseases are prevalent in maintenance hemodialysis （MHD） patients, which is the main cause of death. N-terminal pro-B-type natfiuretic peptide （NT-proBNP）is syn- thesyzed and secreted from cardiac myoeytes in ease of pressure or volume overload. It has been widely used in di- agnosis, treatment,and prognosis of normal people with cardiovascular diseases. A number of studies have shown that NT-proBNP could he used as an important marker for cardiovascular diseases in MHD patients as well. NT- proBNP levels in these populations provide powerful diagnosis information on cardiac structure and function abnor- malities and are predictors of cardiovascular events, mortality and volume overload.