摘要
非胰岛细胞瘤性低血糖(NICTH)是一种胰岛细胞瘤以外的其他肿瘤导致的低血糖症。肿瘤组织分泌过多的胰岛素样生长因子Ⅱ(IGF-Ⅱ)的一种前体形式物质,因其相对分子质量较大,大多数文献称之为big-IGF-Ⅱ,它能产生类胰岛素样活性,故目前认为是导致患者反复出现低血糖的病因。诊断上主要依靠高水平的big-IGF-Ⅱ测定。NICTH的治疗方式较多,但治愈手段主要为手术切除肿瘤组织。现就NICTH的发病机制、临床表现、诊断及治疗等方面的研究进展予以综述。
Non-islet cell tumour-indueed hypoglycaemia（NITCH） is an emergency caused by tumors ex- cept insulinoma. Incompletely processed precursors of IGF- Ⅱ （ big-IGF- U ） is secreted by tumors. Big-IGF- II has insulin-like activity which leads to hypoglycaemia. Diagnosis of NICTH relies on the detection of high lev- el big-IGF- Ⅱ. There are a number of treatments for NICTH, but the major method is to excise the tumor by surgery. Here is to make a review focusing on the pathogenesis, symptoms, diagnosis and treatment of NICTH.
出处
《医学综述》
2013年第2期236-239,共4页
Medical Recapitulate
关键词
非胰岛细胞瘤性低血糖
发病机制
胰岛素样生长因子Ⅱ
临床症状
诊断与治疗
Non-islet cell tumour-induced hypoglycaemia
Pathogenesis
Insulin-like growth factor- Ⅱ
Clinical symptoms
Diagnosis and treatment
