二恶英类化学物质毒性的分子机理

Molecular Mechanisms of Toxicity of Dioxin-type Chemicals

二恶英类化学物质由于其广泛存在及强毒性 ,是人类健康的重要威胁 ,因此二恶英类化学物质的毒性机理受到人们普遍关注。很多学者也对此进行了广泛的研究 ,该文从分子生物学的角度对其毒性机理进行了综述。主要包括 :通过芳香烃受体介导的基因表达。通过芳香烃受体介导的蛋白磷酸化。对营养物质代谢影响的分子机理。

The toxicity mechanisms of dioxin type chemicals had become a worldwide concern because of its ubiquity, high toxicity and a potential health threat to human Many researchers had studied it This article discussing the toxicity mechanisms of dioxin type chemicals from the molecular angle focused on:aromatic hydrocarbons receptor-mediated gene expression and protein phosphorylation,the molecular mechanisms of the effects of dioxin type chemicals on the metabolism of nutrient