慢性肾脏病患者全段甲状旁腺激素水平分析

Clinical application of serum intact parathyroid hormone levels in chronic kidney diseases

目的观察慢性肾脏病(CKD)不同分期患者血清全段甲状旁腺激素(iPTH)与血清肌酐(Scr)、钙、磷的变化。方法测定111例CKD患者及30例健康者(对照组)血清iPTH、Scr、钙、磷水平。结果 CKD3、4、5期患者血清iPTH、Scr、磷水平高于对照组及CKD1、2期患者(P<0.05)。CKD3、4、5期患者血清钙水平低于对照组及CKD1、2期患者(P<0.05)。结论 CKD患者自3期起出现外周血iPTH水平明显升高,发生钙、磷代谢紊乱。

Objective To analyze the changes of serum intact parathyroid hormone（iPTH）, creatinine（Scr）, calcium and phosphorus levels in patient at different periods of chronic kidney diseases（CKD）. Methods Serum iPTH, Scr, calcium and phosphorus levels were detected in 111 patients with CKD and 30 healthy subjects（control group）.Results Serum iPTH, Scr and phosphorus levels in patients at 3, 4 and 5 periods of CKD were higher than those in control group and patients at 1 and 2 periods of CKD, but serum calcium levels were decreased in the latter（P0.05）.Conclusion iPTH levels could be elevated since 3 period of CKD, which could lead to the disorder of calcium and phosphorus metabolism.