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糖尿病患者血清同型半胱氨酸、尿素氮、肌酐、尿酸检测的临床意义 被引量:3

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摘要 目的探讨糖尿病(DM)及其并发症患者血清同型半胱氨酸(Hcy)、尿素氮(Urea)、肌酐(Cr)、尿酸(UA)水平的变化及其临床意义。方法选取健康者(对照组)及单纯DM、糖尿病早期肾损伤(DEKI)、糖尿病肾功能不全(DKF)、糖尿病伴视网膜病变(DRD)、非糖尿病肾功能不全(NDKF)、单纯视网膜病变(RD)患者各30例,进行血清Hcy、Urea、Cr、UA、空腹血糖(Glu)和糖化血红蛋白A1(HbA1c)检测。结果单纯DM及其并发症患者组血清Hcy水平高于对照组(P<0.05),并随着肾损伤的加重而增加;单纯DM组Urea、Crea和UA水平与对照组无统计学差异(P<0.05),但患者出现肾损伤后,其血清水平显著增加;DRD组血清Hcy、Urea、Crea水平高于对照组(P<0.05),但单纯RD组血清Hcy、Urea、Crea、UA水平与对照组无统计学差异(P>0.05);DKF组血清Hcy、Urea、Crea、UA水平高于NDKF组(P<0.05);在糖尿病患者中,高Hcy组血清Urea、Crea和UA水平均高于正常Hcy组(P<0.05)。结论 Hcy、Urea、Cr、UA联合检测对于DM并发肾病的预测和诊断可能具有重要作用。
作者 孙国萍 赵缜
出处 《国际检验医学杂志》 CAS 2013年第1期97-99,共3页 International Journal of Laboratory Medicine
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