冠心病患者血清脂联素水平与高敏C反应蛋白和胰岛素抵抗的关系

The correlation between serum adiponectin and high-sensitivity C-reactive protein and insulin resistance in patients with coronary heart disease

目的探讨血清脂联素水平与不同类型冠心病(CHD)的关系,并分析其与高敏C反应蛋白(hs-CRP)、胰岛素抵抗的关系。方法测定90例CHD确诊患者[稳定型心绞痛(SAP)22例、不稳定型心绞痛(UAP)32例、急性心肌梗死(AMI)36例]及30例体检健康者(对照组)血清脂联素、hs-CRP、空腹血糖、总胆固醇、三酰甘油、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇及胰岛素水平,计算胰岛素抵抗指数(IRI)并测算体质量指数。结果 CHD组血清脂联素水平明显降低(SAP、UAP、AMI依次降低),但SAP组与对照组的差异无统计学意义(P>0.05)。CHD组hs-CRP浓度高于对照组,AMI组高于UAP组和SAP组,UAP组高于SAP组(P<0.05)。血清脂联素水平与hs-CRP、IRI呈负相关。结论血清脂联素和hs-CRP水平检测对CHD的预防、疗效判断和预后判断均有重要价值。

Objective To explore the correlation between serum adiponectin（APN） and three kinds of coronary heart disease（CHD）,and its correlation with high sensitivity C-reactive protein（hs-CRP） and insulin resistance index（IRI）.Methods 90 cases of patients with CHD,including 22 cases of stable angina pectoris（SAP）,32 cases of unstable angina pectoris（UAP） and 36 cases of acute myocardial infarction（AMI） and 30 cases of healthy subjects（control group） were enrolled and detected for serum levels of APN,hs-CRP,fasting blood glucose,total cholesterol,triglyceride,high-density lipoprotein cholesterol,low density lipoprotein cholesterol and fasting blood insulin,and insulin resistance index（IRI） and body-mass index were calculated.Results APN level in CHD group was significantly lower than that in control group,and decreased gradually from SAP group to AMI group,but there was no significant differences between SAP group and control group（P0.05）.About levels of serum CRP,CHD group was higher than control group,AMI group was higher than UAP and SAP group,and UAP group was higher than SAP group（P0.05）.APN level was correlated negatively with CRP and IRI.Conclusion There might be important value of APN and hs-CRP for the prevention,treatment and prognosis of CHD.