肝脏干细胞恶性转化的研究进展

Progress on malignant transformation of hepatic stem cells

越来越多的研究认为，包括肝癌在内的许多恶性肿瘤是干细胞来源的疾病，并且肝癌的发生、耐药、转移及复发与肿瘤内被称作肿瘤干细胞的一小群细胞密切相关。虽然对肝癌及肝癌干细胞的来源仍有争议，但通过近十多年的大量研究，很多学者认为肝癌及肝癌干细胞很有可能是由正常肝脏干细胞在各种致癌因素下发生恶性转化而来的。本文就正常肝脏干细胞恶性转化方面的相关研究进展进行综述。

Compelling evidences have shown that various types of cancer, including hepatocellular carcinoma, are originated from stem cells. The occurrence, chemoresistance, metastasis and recurrence of hepatocellular carci- noma are associated with a small population of cells called ＂cancer stem cells＂. Although the origin of hepatocellu- lar carcinoma and hepatic cancer stem cells remain controversial after a decade of intensive investigation, increasing scholars tend to believe that hepatocellular carcinoma and hepatic cancer stem cells can derive from malignant trans- formation of hepatic stem ceils being exposed to various kinds of carcinogens. In this review, we mainly focus on the recent progress on malignant transformation of hepatic stem ceils .