补肾活血颗粒治疗帕金森病临床研究

Clinical Study of Bushen Huoxue Granule in Treatment of Parkinson’s Disease

目的观察补肾活血颗粒治疗帕金森病的临床疗效。方法采用随机、单盲双模拟对照试验,将88例帕金森病患者随机分为补肾活血颗粒组45例和对照组43例。补肾活血颗粒组服用补肾活血颗粒加西药安慰剂;对照组服用美多巴及中药安慰剂。疗程为3个月。观察治疗前后2组患者帕金森病评定量表(UPDRS)和中医证候量表的积分变化。结果补肾活血颗粒组治疗后UPDRS评分为(51.2±5.7)分,与治疗前(55.3±6.8)分比较差异有统计学意义(P<0.05),与对照组治疗后(49.6±6.8)分比较差异无统计学意义(P>0.05)。由UPDRS量表计算其进步率,补肾活血颗粒组为77.8%,对照组为81.4%,2组比较差异无统计学意义(P>0.05)。补肾活血颗粒组治疗后中医证候量表评分为(19.2±3.2)分,与治疗前(23.5±3.6)分比较差异有统计学意义(P<0.05),与对照组治疗后(21.4±4.5)分比较差异有统计学意义(P<0.05)。按中医证候量表计算其总有效率,补肾活血颗粒组为88.9%,对照组为39.5%,2组比较差异有统计学意义(P<0.05)。结论补肾活血颗粒治疗帕金森病效果良好,主要体现在改善患者中医临床症状方面。

Objective To evaluate the efficacy of Bushen Huoxue Granule（BSHXG）,a compound traditional Chinese herbal medicine for reinforcing kidney and activating blood circulation,in treatment of Parkinson’s disease（PD）.Methods A randomized,single-blind,placebo-controlled clinical study was undertaken.Eighty-eight PD patients were randomly divided into BSHXG group and control group.The control group of 43 cases was treated with western medicine and placebo,while the BSHXG group of 45 cases was treated with BSHXG and placebo.All patients were treated for 3 months.Unified Parkinson’s Disease Rating Scale（UPDRS） and Scale of TCM Syndrome for PD of all objects were measured before and after treatment.Results After three months treatment,the score of UPDRS in BSHXG group was 51.2±5.7,compared with before treatment（55.3±6.8）,it was significantly improved（P〈0.05）,while compared with the control group（49.6±6.8）,the difference was not significant（P〈0.05）.The progress rate in BSHXG group was 77.8%,compared with that in control group（81.4%）,the difference was not significant（P〈0.05）.The score of Scale of TCM Syndrome for PD in BSHXG group was 19.2±3.2,compared with before treatment（23.5±3.6）,it was significantly improved（P〈0.05）,and compared with that in control group（21.4±4.5）,it was significantly lowered（P〈0.05）.BSHXG group showed a higher efficacy（88.9%） than the control group（39.5%） in improving TCM symptoms（P〈0.05）.Conclusions BSHXG is effective and safe in treating PD patients.BSHXG can markedly improve TCM symptoms of Parkinson’s patients.