复方丹参滴丸治疗冠心病心绞痛的有效性和安全性系统评价

Systematic Evaluation of Efficacy and Safety of Compound Salvia Droplet Pills for Angina Pectoris

目的评价复方丹参滴丸治疗冠心病心绞痛的有效性和安全性。方法计算机检索外文数据库(Cochrane library网络版)、中文数据库(中国生物医学数据库、中国期刊全文数据库、中文科技期刊全文数据库、万方数字化期刊全文库),按Cochrane系统评价的方法评价纳入研究质量,对同质研究采用RevMan5.0进行Meta分析,对数据不能合并者,则进行描述性定性分析。结果复方丹参滴丸缓解冠心病心绞痛的发作(比值比=2.18,95%可信区间[1.75,2.70],P<0.000 01),改善缺血心电图(比值比=2.39,95%可信区间[1.99,2.88],P<0.000 01),降低胆固醇(加权均数差为1.31,95%可信区间[1.03,1.58],P<0.000 01)、降低三酰甘油(加权均数差为2.05,95%可信区间[1.65,2.45],P<0.000 01),提高心率变异性,未发现明显不良反应。结论基于当前证据,复方丹参滴丸治疗冠心病心绞痛确有疗效;未见严重的不良反应,提示复方丹参滴丸在治疗冠心病心绞痛时安全性较好,不良反应小,是治疗冠心病心绞痛的有效安全的中成药。

Objective To evaluate the efficacy and safety of Compound Salvia Droplet Pills （CSDP） for treating angina peetoris. Methods Foreign database （ Coehrane Library online edition） and Chinese database （ Chinese Biomedical Database, China Academic Journal Full-text Database of Chinese Scientific Journals, and Waiffang Digital Journal Full-text Database） were retrieved via internet, according to Cochr/me systematic review method of quality evaluation. Meta-analysis of homogeneous studies was carried out with RevMan 5.0, and deseriptive qualitative analysis was performed for the data could not be merged. Results The results showed that CSDP alleviated the onset of angina pectoris （ OR = 2. 18, 95% CI [ 1.75,2.70 ] , P〈0. 000 01 ） , improved isehemie ECG（ OR=2.39,95% CI ~ 1.99,2.88] ,P〈0. 000 01 ） , lowered cholesterol（ WMD= 1.31, 95% CI E 1.03, 1.58],P〈0.000 01） and triaeylglyeerol（WMD=2.05, 95%CI [1.65,2.45~,P〈0.000 01）, and raised the heart rate variability, and presented no obvious side effects. Conclusion CSDP demonstrated curative effect on angina pectoris, and no obvious side effects, which suggest that CSDP are effective and safe for treating angina pectoris.