2010年～2011年衡阳地区泌尿系感染病原菌调查和药敏谱分析

Pathogen Investigation and Drug Susceptibility Spectrum Analysis in Nosocomial Urinary Tract Infections in Hengyang Area During 2010～2011

目的探讨衡阳地区泌尿系感染病原菌的分布及其对抗菌药物的耐药性,以指导临床合理用药。方法对2010年1月～2011年12月两年间泌尿系感染的中段尿进行细菌培养、分离鉴定,并进行药敏试验。结果共有尿培养5 013例,检出1 505株病原菌,检出率为30.0%。尿路感染中最常见的病原菌是大肠埃希氏菌,占52.1%,其次是肠球菌属,占11.5%,真菌占10.3%;泌尿系感染病原菌革兰阴性杆菌对亚胺培南、美罗培南较为敏感,葡萄球菌和肠球菌属对万古霉素、呋喃妥因较为敏感,其它菌株对常用抗菌药物均产生了一定的耐药性。结论泌尿系感染病原菌的耐药严重,临床应尽早进行细菌培养和药敏试验,合理选择抗菌药物。

Objective To investigate the bacterial distribution and antibiotic resistance situation of main pathogens with urinary tract infection （UTI） in Henayang area for the guidance of rational use of antibiotics. Methods The antibi- otic resistance of clinical isolates patgogens were studied from urinary tract infection by routine bacterium culture in our hos- pital from Jan 2010 to Dee 2011. Result There were 1 505 strains of pathogens in the whole 5 013 unary samples,and the isolating rate was 30.0%. The most common pathogen in urinary tract infection was Escherichia coli （52.1% ） ,then the Enteroeoceus （ 11.5% ） ,and the fungi was 10.3%. Gram-negative bacilli was found to be sensitive to imipenem and Mero- penem, while staphylococci and Enterococcus were sensitive to furadantin and vancomycin, and the other strains were highly resistant to some antibiotics. Conclusion The resistantce of pathogenic bacteria is serious among the urinary tract infec- tion. We should carry through cultivation, isolation, and antimicrobial susceptibility testing as soon as possible in clinical jobs to guide reasonable clinical drug therapy.