358株肺炎克雷伯菌的临床分布及耐药性分析

Clinical Distribution and Drug Resistance of 358 Strains of Klebsiella Pneumoniae

目的分析肺炎克雷伯菌的临床分布及耐药情况,为临床合理使用抗生素提供依据。方法采用回顾性调查的方法对358株肺炎克雷伯菌的标本来源及耐药性进行分析。结果 358株肺炎克雷伯菌中,产ESBLs阳性142株,阳性率为39.7%;ESBLs阳性的肺炎克雷伯菌对所测抗菌药物耐药性显著高于产ESBLs阴性菌,并且出现2株对亚胺培南耐药的肺炎克雷伯菌。结论产ESBLs肺炎克雷伯菌在医院感染中十分流行,多重耐药明显。

Objective To analyse the clinical distribution of Klebsiella pneumoniae and its drug resistance to pro- vide the basis for rational clinical use of antibiotics. Methods Clinical distribution and antibiotic resistance of 358 strains of Klebsiella pneumoniae, isolated from various clinical samples, were retrospectively analyzed. Results In 358 K. pneumoniae,the positive rate of ESBLs was 39.7% in 142 strains of ESBLs-produeing K. pneumoniae;the drug re- sistance rate of ESBLs-producing K. pneumoniae was higher than that of non-ESBLs-produeing strains. Moreover, there were two strains of imipenem resistant K. pneumoniae. Conclusion Klebsiella pneumoniae,producing ESBLs,might be preva- lent in hospital, with significant multi-drug resistance.